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Titolo:
Activity of the adenylyl cyclase in lymphocytes of male alcoholic patientsis state dependent
Autore:
Szegedi, A; Anghelescu, I; Pauly, T; Dahmen, N; Muller, MJ; Wetzel, H; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 9, volume: 22, anno: 1998,
pagine: 2073 - 2079
SICI:
0145-6008(199812)22:9<2073:AOTACI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-FOSTERING ANALYSIS; BINDING-PROTEINS; EXPRESSION; INHERITANCE; ETHANOL; CAMP; MEN;
Keywords:
alcohol; adenylyl cylase; lymphocytes; state dependent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Szegedi, A Univ Mainz, Dept Psychiat, Untere Zahlbacherstr 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacherstr 8 Mainz Germany D-55131 ermany
Citazione:
A. Szegedi et al., "Activity of the adenylyl cyclase in lymphocytes of male alcoholic patientsis state dependent", ALC CLIN EX, 22(9), 1998, pp. 2073-2079

Abstract

A decreased basal and/or stimulated activity of the G-protein/adenylyl cyclase (AC) system in peripheral blood cells has been proposed to represent atrait marker for alcoholism. However, AC activity may underlie state-dependent changes, which may impair a proper interpretation of AC activity measurements. Our study examined systematically the AC activity in peripheral lymphocytes of 73 male alcohol-dependent patients (according to DSM-IV criteria) at three different time points of measurement during the clinical course of detoxification (day 0 = at admission, while still ethanol-affected; day 2 = at the presumed peak of withdrawal symptoms; day E = after detoxification). Basal and stimulated (with GTP gamma S and forskolin) AC activities were measured. AC activities were compared to those of a control group of 44 healthy male age-matched volunteers. As our main finding, we detected a significant decrease in AC activity from day 0 to day 2 (during withdrawal),with lowered AC activities in a vast majority of patients. This effect resolved after detoxification, as AC activities showed a significant increase from day 2 to E. No significant difference was detected between day 0 and Ein AC activities of the patients. Compared with controls, AC activities inpatients were significantly lower at day 2, but not at day 0 and E. Taken together, our results indicate rapid and marked state-dependent changes of AC activities in alcohol-dependent patients during the course of detoxification. For an adequate interpretation of AC activities in alcoholic patients, their clinical status must be taken into consideration.

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Documento generato il 28/01/20 alle ore 15:58:47