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Titolo:
Linkage of an alcoholism-related severity phenotype to chromosome 16
Autore:
Foroud, T; Bucholz, KK; Edenberg, HJ; Goate, A; Neuman, RJ; Porjesz, B; Koller, DL; Rice, J; Reich, T; Bierut, LJ; Cloninger, CR; Nurnberger, JI; Li, TK; Conneally, PM; Tischfield, JA; Crowe, R; Hesselbrock, V; Schuckit, M; Begleiter, H;
Indirizzi:
Washington Univ, Sch Med, St Louis, MO USA Washington Univ St Louis MO USA shington Univ, Sch Med, St Louis, MO USA SUNY, Ctr Hlth Sci, Brooklyn, NY USA SUNY Brooklyn NY USASUNY, Ctr Hlth Sci, Brooklyn, NY USA Univ Iowa, Sch Med, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 v Iowa, Sch Med, Iowa City, IA 52242 USA Univ Connecticut, Sch Med, Farmington, CT USA Univ Connecticut FarmingtonCT USA necticut, Sch Med, Farmington, CT USA Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ch Med, La Jolla, CA 92093 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 9, volume: 22, anno: 1998,
pagine: 2035 - 2042
SICI:
0145-6008(199812)22:9<2035:LOAASP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR GENE; ALDEHYDE DEHYDROGENASE GENOTYPES; MNS BLOOD-GROUP; ALLELIC ASSOCIATION; JAPANESE ALCOHOLICS; NO ASSOCIATION; USE DISORDERS; SUBSTANCE USE; ESTERASE-D; AL ALLELE;
Keywords:
alcoholism; linkage; latent class analysis; chromosome 16;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Foroud, T Indiananapolis,ch Med, Dept Med & Mol Genet, 975 W Walnutt St IB-155, India Indiana Univ 975 W Walnutt St IB-155 Indianapolis IN USA 46202 a
Citazione:
T. Foroud et al., "Linkage of an alcoholism-related severity phenotype to chromosome 16", ALC CLIN EX, 22(9), 1998, pp. 2035-2042

Abstract

There is substantial evidence for a significant genetic component to the risk for alcoholism In searching for genes that contribute to this risk, thediagnostic criteria for alcohol dependence may not be the optimal phenotype; rather, creation of a more homogeneous phenotype will lead to a more homogeneous genetic etiology. Items from the Semi-Structured Assessment for the Genetics of Alcoholism collected from 830 individuals in 105 alcoholic families were used in a latent class analysis to identify a more homogeneous alcoholism-related phenotype. A four-class solution was chosen: class 1, unaffected group; class 2, mildly problematic group; class 3, moderately affected group; and class 4, severely affected group. Classes 3 and 4 had higher symptom endorsement probabilities than classes 1 and 2 for items reflecting severe alcohol dependence, and were combined to provide enough sibling pairs for genetic linkage analysis. A total of 291 markers distributed throughout the genome, with an average intermarker distance of 14 cM, were genotyped. Linkage analysis was performed to detect loci underlying classes 3 and 4, the moderately and severely affected alcoholics, of whom 88% met the Collaborative Study of the Genetics of Alcoholism, and >99% met ICD-10 criteria for alcohol dependence. Evidence for a locus on chromosome 16, near themarker D16S675, was found with a maximum multipoint lod score of 4.0. Analysis of additional markers on chromosome 16 yielded a rod score of 3.2, narrowed the critical region, and placed the gene between D16S475 and D16S675 in a 15 cM interval.

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Documento generato il 21/09/20 alle ore 12:42:54