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Titolo:
Protective effect of P-fraternus against ethanol-induced mitochondrial dysfunction
Autore:
Sebastian, T; Setty, OH;
Indirizzi:
Univh,yderabad, Sch Life Sci, Dept Biochem, Hyderabad 500046, Andhra Prades Univ Hyderabad Hyderabad Andhra Pradesh India 500046 00046, Andhra Prades
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 17, anno: 1999,
pagine: 29 - 34
SICI:
0741-8329(199901)17:1<29:PEOPAE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; PHYLLANTHUS-NIRURI; HEPATOPROTECTIVE ACTIVITY; HEPATIC MITOCHONDRIA; CYTOCHROME-OXIDASE; CONSUMPTION; PARTICLES;
Keywords:
chronic ethanol consumption; oxidative phosphorylation; mitochondrial dysfunction; Phyllanthus fraternus; electron transport chain; P/O ratio; respiratory control ratio;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Setty, OH Univh,yderabad, Sch Life Sci, Dept Biochem, Hyderabad 500046, Andhra Prades Univ Hyderabad Hyderabad Andhra Pradesh India 500046 hra Prades
Citazione:
T. Sebastian e O.H. Setty, "Protective effect of P-fraternus against ethanol-induced mitochondrial dysfunction", ALCOHOL, 17(1), 1999, pp. 29-34

Abstract

Chronic ethanol consumption (10 g per kg body weight) significantly decreased the rate of respiration, P/O ratio, and respiratory control ratio (RCR). The activities of NADH dehydrogenase and cytochrome oxidase were significantly decreased in submitochondrial particles by ethanol administration compared to control. No significant difference was observed in membrane potential of submitochondrial particles. Cytochrome b, c and aa(3) content of mitochondria were significantly decreased by ethanol feeding. Ethanol-induced inhibition on rate of respiration, P/O ratio, and RCR was relieved to a great extent by the administration of the aqueous extract of Phyllanthus fraternus (100 mg dry powder of the plant per kg body weight) along with ethanol. The decrease in the content of cytochromes due to ethanol administration was revived partially by aqueous extract of P. fraternus. (C) 1998 ElsevierScience Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:33:00