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Titolo:
Emergence of epidemic O'nyong-nyong fever in Uganda after a 35-year absence: Genetic characterization of the virus
Autore:
Lanciotti, RS; Ludwig, ML; Rwaguma, EB; Lutwama, JJ; Kram, TM; Karabatsos, N; Cropp, BC; Miller, BR;
Indirizzi:
US,Divt HHS, Publ Hlth Serv, Ctr Dis Control & Prevent, Natl Ctr Infect Dis US Dept HHS Ft Collins CO USA Dis Control & Prevent, Natl Ctr Infect Dis Uganda Virus Res Inst, Entebbe, Uganda Uganda Virus Res Inst Entebbe Uganda da Virus Res Inst, Entebbe, Uganda
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 252, anno: 1998,
pagine: 258 - 268
SICI:
0042-6822(199812)252:1<258:EOEOFI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-SEQUENCE; SINDBIS VIRUS; ALPHAVIRUSES; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lanciotti, RS US,Divt HHS, Publ Hlth Serv, Ctr Dis Control & Prevent, NatlCtr Infect Dis US Dept HHS Ft Collins CO USA Prevent, Natl Ctr Infect Dis
Citazione:
R.S. Lanciotti et al., "Emergence of epidemic O'nyong-nyong fever in Uganda after a 35-year absence: Genetic characterization of the virus", VIROLOGY, 252(1), 1998, pp. 258-268

Abstract

O'nyong-nyong (ONN) virus is an alphavirus (family Togaviridae, genus Alphavirus) classified in the Semliki Forest virus (SFV) antigenic complex. ONNwas initially isolated in northern Uganda in 1959 during the early stages of an explosive arbovirus epidemic in which >2 million cases were reported. No additional epidemics or human isolations of ONN were reported until 1996, when it was isolated from an epidemic in southern Uganda. We report the complete nucleotide and deduced amino acid sequence of one of these 1996-1997 ONN isolates (SG650) and that of the related alphavirus Igbo Ora virus. The data indicate that the recent ONN virus isolate is closely related to the previously published ONN strain isolated in 1959. In addition, phylogenetic analysis of the sequence data reveals that Igbo Ora virus, previously thought to be a separate virus closely related to ONN and Chikungunya (CHIK), clearly is a strain of ON N. The sequence data also reveal that unlike the published ONN (1959) sequence, all ONN strains from the 1996-1997 epidemic possess a stop codon at the nsp3-nsp4 junction. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:11:33