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Titolo:
Shortening velocity is different in longitudinal and circular muscle layers of the rabbit urethra
Autore:
Arner, A; Mattiasson, A; Radzizewski, P; Uvelius, B;
Indirizzi:
Univ Lund Hosp, Dept Urol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 sp, Dept Urol, SE-22185 Lund, Sweden Univ Lund, Dept Physiol & Neurosci, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Physiol & Neurosci, Lund, Sweden
Titolo Testata:
UROLOGICAL RESEARCH
fascicolo: 6, volume: 26, anno: 1998,
pagine: 423 - 426
SICI:
0300-5623(199812)26:6<423:SVIDIL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKINNED SMOOTH-MUSCLE; PIG TAENIA-COLI; GUINEA-PIG; ISOFORM COMPOSITION; URINARY-BLADDER; FORCE; RAT;
Keywords:
force-velocity relation; rabbit; urethra; lactate dehydrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Uvelius, B Univ Lund Hosp, Dept Urol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 ol, SE-22185 Lund, Sweden
Citazione:
A. Arner et al., "Shortening velocity is different in longitudinal and circular muscle layers of the rabbit urethra", UROL RES, 26(6), 1998, pp. 423-426

Abstract

The aim of the study was to investigate whether the functional difference between circular and longitudinal muscles in the female rabbit urethra is reflected in their shortening properties and lactate dehydrogenase (LDH) activity. For mechanical experiments the preparations were chemically skinned to avoid influence of membrane-related mechanisms and to enable maximal activation. Force-velocity relations and the maximal shortening velocity (v(max)) were determined using the isotonic quick-release method. The v(max) wasthree times higher in longitudinal muscle. LDH isoform pattern was determined on agarose gels. The M-subunit, favourable for lactate formation, constituted 70% of the total in both types of muscle. There was no difference inthe LDH isoform pattern despite the marked difference in v(max). We conclude that the difference in v(max) reflects differences in the contractile machinery itself. These mechanical characteristics are advantageous for the role of the circular as a tonic muscle contracting during bladder filling, and the longitudinal as a phasic muscle active in opening up the urethra during micturition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:40:29