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Titolo:
Ethanol tolerance and synaptic plasticity
Autore:
Chandler, LJ; Harris, RA; Crews, FT;
Indirizzi:
Louisiana1130te Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 7 Louisiana State Univ Shreveport LA USA 71130 Therapeut, Shreveport, LA 7 Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Mol & Cellular Biol, Austin, TX 78712 USA Univ N Carolina, Sch Med, Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Pharmacol & Psychiat, Chapel Hill, NC 27599 USA UnivN Carolina Chapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 12, volume: 19, anno: 1998,
pagine: 491 - 495
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; PROTEIN-KINASE-C; OPERATED CHLORIDE CHANNELS; LONG-TERM POTENTIATION; NMDA-RECEPTOR; GABA(A) RECEPTORS; CORTICAL-NEURONS; NR1 SUBUNIT; TYROSINE PHOSPHORYLATION; HIPPOCAMPAL-NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Chandler, LJ Louisianaay,ate Univ, Med Ctr, Dept Pharmacol & Therapeut, 1501 Kings Highw Louisiana State Univ 1501 Kings Highway Shreveport LA USA 71130
Citazione:
L.J. Chandler et al., "Ethanol tolerance and synaptic plasticity", TRENDS PHAR, 19(12), 1998, pp. 491-495

Abstract

Current concepts of the mechanisms underlying many of the pharmacological effects of ethanol on the CNS involve disruption of ion channel function via the interaction of ethanol with specific hydrophobic sites on channel subunit proteins. Of particular clinical importance is the development of tolerance and dependence to ethanol, and it is likely that adaptive changes in synaptic function in response to ethanol's actions on ion channels play a role in this process. In this article, Judson Chandler, Adron Harris and Fulton Crews discuss potential mechanisms of ethanol-induced changes in synaptic function that might provide a cellular basis for ethanol tolerance and dependence. It is proposed that multiple mechanisms are involved that include both transcriptional and past-translational modifications in NMDA and GABA(A) receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 16:51:06