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Titolo:
Mitochondrial activity in the mapping of functional brain changes in schizophrenia
Autore:
Prince, JA; Oreland, L;
Indirizzi:
Uppsala Univ, Dept Med Pharmacol, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 d Pharmacol, S-75124 Uppsala, Sweden
Titolo Testata:
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
fascicolo: 2-3, volume: 12, anno: 1998,
pagine: 185 - 193
SICI:
0922-6028(199806)12:2-3<185:MAITMO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PREVIOUS METHAMPHETAMINE PSYCHOSIS; DOPAMINE D4 RECEPTORS; MEDIAL TEMPORAL-LOBE; CYTOCHROME-OXIDASE; ENERGY-METABOLISM; PREFRONTAL CORTEX; BASAL GANGLIA; RAT-BRAIN; CEREBRAL METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Oreland, L Uppsala Univ, Dept Med Pharmacol, Box 593, S-75124 Uppsala, Sweden Uppsala Univ Box 593 Uppsala Sweden S-75124 24 Uppsala, Sweden
Citazione:
J.A. Prince e L. Oreland, "Mitochondrial activity in the mapping of functional brain changes in schizophrenia", REST NEUROL, 12(2-3), 1998, pp. 185-193

Abstract

The main contributors to the search for functional brain changes in schizophrenia in the past years have employed imaging techniques such as positronemission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI). Our laboratory has)applied a novel strategy involving the post-mortem measurement of the mitochondrial respiratory chain enzyme cytochrome-c oxidase (COX) to address the question of regional metabolic changes in schizophrenia. This approach is based upon a strong body of evidence which indicates that neuronal COX is highly regulated by the energy demands of the cell and as such represents an endogenous marker of cellular energy metabolism over time. Our original findings indicated that COX activity may be reduced in the striatum and frontal cortex consistent with the concept that a state reduced activity in cortico-striatal circuits may underlie schizophrenia. Subsequent studies from our laboratoryon the effects of neuroleptics, PCP, and methamphetamine on animals, have provided additional evidence that a state of dopaminergic overactivity or glutamatergic underactivity produces a hypometabolic state similar to that which is evident in the brains of schizophrenics.

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Documento generato il 20/01/20 alle ore 15:59:46