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Titolo:
Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide
Autore:
Rammes, G; Zeilhofer, HU; Collingridge, GL; Parsons, CG; Swandulla, D;
Indirizzi:
Max Planck Inst Psychiat, Abt Neuropharmakol, D-80804 Munich 40, Germany Max Planck Inst Psychiat Munich Germany 40 l, D-80804 Munich 40, Germany Univgen,angen Nurnberg, Dept Expt & Clin Pharmacol & Toxicol, D-91054 Erlan Univ Erlangen Nurnberg Erlangen Germany D-91054 & Toxicol, D-91054 Erlan Med Sch Bristol, Dept Anat, Bristol BS8 1TD, Avon, England Med Sch Bristol Bristol Avon England BS8 1TD istol BS8 1TD, Avon, England Merz & Co, Dept Pharmacol, D-60318 Frankfurt, Germany Merz & Co Frankfurt Germany D-60318 harmacol, D-60318 Frankfurt, Germany
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 2, volume: 437, anno: 1999,
pagine: 191 - 196
SICI:
0031-6768(199901)437:2<191:EOEHCL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; EXCITATORY POSTSYNAPTIC CURRENTS; GLUTAMATE-RECEPTOR CHANNELS; SYNAPTIC MECHANISMS; WAVE-FORM; NEURONS; ANIRACETAM; SLICES; DESENSITIZATION; MODULATION;
Keywords:
AMPA receptor-mediated EPSCs; cyclothiazide; hippocampus; kinetics; long-term potentiation (LTP); rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Rammes, G Maxchlanck Inst Psychiat, Abt Neuropharmakol, Kraepelin Str 2, D-80804 Muni Max Planck Inst Psychiat Kraepelin Str 2 Munich Germany 40 Muni
Citazione:
G. Rammes et al., "Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide", PFLUG ARCH, 437(2), 1999, pp. 191-196

Abstract

We have analysed whether the expression of long-term potentiation (LTP) inrat hippocampal CA1 neurons involves a change in the kinetics of (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated excitatory postsynaptic currents (EPSCs) (AMPA-EPSCs) or their susceptibility to the AMPA receptor modulator cyclothiazide. AMPA-EPSCs in the CA1 region were evoked by alternate stimulation of two independent Schaffer collateral-commissural inputs of slices of adult rat hippocampus. In the current-clamp mode a strong tetanus (100 Hz, 1 s) applied to one input (input I) induced stable LTP of AMPA-EPSCs in this input, while the control input (input II) remained unaffected. For neither input were EPSC rise time and decaykinetics significantly changed. The application of cyclothiazide prolongedthe rise time and the decay time constants of the AMPA-EPSCs in both control and potentiated inputs to the same extent (Input I-rise time: 198 +/- 8%, decay: 148 +/- 12%; input II-rise time: 212 +/- 14%, decay: 144 +/- 19%; n = 8). Furthermore, when present during tetanization cyclothiazide did notocclude LTP, suggesting that cyclothiazide and tetanic stimulation enhanceAMPA-EPSCs via independent mechanisms. Our findings argue against changes in (de-)activation or desensitization of AMPA receptors as the molecular basis for the expression of LTP.

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Documento generato il 05/07/20 alle ore 00:47:17