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Titolo:
Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains
Autore:
Ikeda, K; Akiyama, H; Arai, T; Kondo, H; Haga, C; Iritani, S; Tsuchiya, K;
Indirizzi:
Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan TokyoMetropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 258, anno: 1998,
pagine: 113 - 116
SICI:
0304-3940(199812)258:2<113:ALIGIA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; ALZ-50 IMMUNOREACTIVITY; CATHEPSIN-D; TAU; HYPOTHALAMUS; SEQUENCE; SYSTEM; RAT;
Keywords:
lysosome; lipofuscin; tau; neurofibrillary tangles; Alz-50; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, K Tokyoyonst Psychiat, Dept Neuropathol, Setagaya Ku, 2-1-8 Kamikitazawa, Tok Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 , Tok
Citazione:
K. Ikeda et al., "Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains", NEUROSCI L, 258(2), 1998, pp. 113-116

Abstract

The Gallyas-Braak silver impregnation method revealed neurons containing well-defined intraneuronal granules in both Alzheimer's disease and normal control brains. The granules were immunostained prominently with the Alz-50 antibody and, to a lesser degree, with the tau-e antibody, but not with other anti-tau antibodies examined. The areas of distribution of granule-containing neurons detected by the Gallyas-Braak method appeared to overlap withthe reported main sites of subcortical distribution of neurofibrillary tangles. They, however, were not observed in the cerebral cortex, including the hippocampal region. The Alz-50 immunoreactive granules showed ultrastructural features similar to those of lysosomes or lipofuscin. These findings suggest that denatured tau might be degraded in lysosomes. (C) 1998 ElsevierScience Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:38:24