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Titolo:
Serotonergic and noradrenergic markers of post-traumatic stress disorder with and without major depression
Autore:
Maes, M; Lin, AH; Verkerk, R; Delmeire, L; Van Gastel, A; Van der Planken, M; Scharpe, S;
Indirizzi:
Univ60ntwerp, AZ Stuivenberg, Clin Res Ctr Mental Hlth, Dept Psychiat, B-20 Univ Antwerp Antwerp Belgium B-2060 Ctr Mental Hlth, Dept Psychiat, B-20 Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA IRCSS, Brescia, Italy IRCSS Brescia ItalyIRCSS, Brescia, Italy Univ Antwerp, Dept Med Biochem, Wilrijk, Belgium Univ Antwerp Wilrijk Belgium ntwerp, Dept Med Biochem, Wilrijk, Belgium Univ Antwerp Hosp, Dept Hematol, Antwerp, Belgium Univ Antwerp Hosp Antwerp Belgium Hosp, Dept Hematol, Antwerp, Belgium
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 20, anno: 1999,
pagine: 188 - 197
SICI:
0893-133X(199902)20:2<188:SANMOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; NEUTRAL AMINO-ACIDS; HUMAN-PLATELET; CATECHOLAMINE EXCRETION; URINARY NOREPINEPHRINE; PLASMA NOREPINEPHRINE; ALPHA-ADRENOCEPTORS; 5-HT UPTAKE; TYROSINE; TRYPTOPHAN;
Keywords:
post-traumatic stress disorder; depression; serotonin; norepinephrine; tryptophan; tyrosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Maes, M UniveAntwerp, AZ Stuivenberg, Clin Res Ctr Mental Hlth, Dept Psychiat, Lang Univ Antwerp Lange Beeldekensstr 267 Antwerp Belgium B-2060 Lang
Citazione:
M. Maes et al., "Serotonergic and noradrenergic markers of post-traumatic stress disorder with and without major depression", NEUROPSYCH, 20(2), 1999, pp. 188-197

Abstract

Some studies have suggested that disorders ill the peripheral and central metabolism of serotonin (5-HT) and noradrenaline (NE) may play roles in thepathophysiology of post-traumatic stress disorder (PTSD). This study examines (1) the availability of plasma total tryptophan, the precursor of 5-HT,and tyrosine, the precursor of NE; and (2) the platelet 5-HT transporter and alpha 2-adrenoceptor (alpha 2-AR) binding sites ill patients with PTSD and healthy volunteers. High-performance liquid chromatography (HPLC) was employed to measure plasma tryptophan and tyrosine as well as amino acids known to compete with the same cerebral transport system; that is, valine, leucine, phenylalanine, and isoleucine. The maximum number of binding sites (B-max) and their affinity (Kd) for binding to [H-3]-paroxetine and [H-3]-rauwolscine, a selective alpha 2-AR antagonist, were determined. [H-3]-paroxetine and [H-3]-rauwolscine binding Kd values were significantly higher in patients with PTSD than in healthy volunteers. [H-3]-rauwolscine binding Kd values were significantly higher in patients with PTSD and concurrent major depression (MD) than in PTSD patients without MD and healthy volunteers. Plasma tyrosine concentrations and the ratio of tyrosine/valine + leucine + isoleucine phenylalanine + tryptophan were significantly higher in PTSD patients with MD than in those without MD and healthy volunteers. The results show that PTSD is accompanied by lower affinity of paroxetine binding sites and that PTSD with concurrent MD is accompanied by lower affinity of alpha 2-ARs and increased plasma tyrosine availability to the brain. The results suggest that (1) serotonergic mechanisms, such as defects in the 5-HT transporter system, may play a role in the pathophysiology of PTSD; and (2) thatcatecholaminergic mechanisms, such as increased precursor availability andlowered affinity of alpha 2-ARs, may play a role ill the pathophysiology of PTSD with concurrent MD. [Neuropsychopharmacology 20: 188-197, 1999] (C) 1998 American College of Neuropsychopharmacology.. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:46:31