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Titolo:
Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners
Autore:
Broocks, A; Meyer, T; George, A; Hillmer-Vogel, U; Meyer, D; Bandelow, B; Hajak, G; Bartmann, U; Gleiter, CH; Ruther, E;
Indirizzi:
Univ Gottingen, Dept Psychiat, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 iat, D-37075 Gottingen, Germany Univ Wurzburg, Dept Neurol, Wurzburg, Germany Univ Wurzburg Wurzburg Germany Wurzburg, Dept Neurol, Wurzburg, Germany Univ Gottingen, Dept Clin Pharmacol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 col, D-37075 Gottingen, Germany Univ Gottingen, Dept Sports Med, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Med, D-37075 Gottingen, Germany Univ Saarbrucken, Inst Sports & Prevent Med, Saarbrucken, Germany Univ Saarbrucken Saarbrucken Germany Prevent Med, Saarbrucken, Germany
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 20, anno: 1999,
pagine: 150 - 161
SICI:
0893-133X(199902)20:2<150:DNRTM(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEMISTARVATION-INDUCED HYPERACTIVITY; PITUITARY-ADRENAL AXIS; AEROBIC EXERCISE; CEREBROSPINAL-FLUID; PHYSICAL EXERCISE; BETA-ENDORPHIN; ENDURANCE PERFORMANCE; RECEPTOR ACTIVATION; TREADMILL EXERCISE; BEHAVIORAL STRESS;
Keywords:
exercise; marathon running; serotonin; meta-chlorophenylpiperazine (m-CPP); ipsapirone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Broocks, A UnivyGottingen, Dept Psychiat, Von Siebold Str 5, D-37075 Gottingen, German Univ Gottingen Von Siebold Str 5 Gottingen Germany D-37075 man
Citazione:
A. Broocks et al., "Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners", NEUROPSYCH, 20(2), 1999, pp. 150-161

Abstract

Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. After administration of the nonselective serotonergic agonist m-CPP, which exerts a number of well-reproducible effects mainly by means of its action of 5-HT2C receptors, marathon runners showed a significantly reduced cortisol response in comparison to the control group. There was also a statistical trend toward a blunted prolactin response after m-CPP in the athlete group. In contrast, the increase of cortisol and thehypothermia observed after administration of the 5-HT1A agonist ipsapironewere of the same magnitude in both groups. The behavioral response to nz-CPP or ipsapirone and the mean maximal increases of plasma adrenaline and noradrenaline did not differ between the marathon and the control group. In conclusion, exercise-induced downregulation of 5-HT2C receptors could play an important role in mediating the anxiolytic and antidepressive effects of exercise. [Neuropsychopharmacology 20:150-162, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:23:33