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Titolo:
Guanfacine and clonidine, alpha2-agonists, improve paired associates learning, but not delayed matching to sample, in humans
Autore:
Jakala, P; Sirvio, J; Riekkinen, M; Koivisto, E; Kejonen, K; Vanhanen, M; Riekkinen, P;
Indirizzi:
Univ Kuopio, Dept Neurosci & Neurol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 & Neurol, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Kuopio, Finland Kuopio Univ Hosp Kuopio FinlandKuopio Univ Hosp, Kuopio, Finland Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 20, anno: 1999,
pagine: 119 - 130
SICI:
0893-133X(199902)20:2<119:GACAIP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-2-ADRENERGIC RECEPTOR SUBTYPE; LOCUS COERULEUS NEURONS; TEMPORAL-LOBE EXCISIONS; CENTRAL-NERVOUS-SYSTEM; WORKING-MEMORY; NORADRENERGIC MODULATION; AGED MONKEYS; FRONTAL-LOBE; AMYGDALO-HIPPOCAMPECTOMY; VISUOSPATIAL MEMORY;
Keywords:
learning and memory; cognitive functions; clonidine; guanfacine; noradrenaline; alpha2-adrenoceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Riekkinen, P Kuopiondniv Hosp, Dept Neurosci & Neurol, POB 1627, FIN-70211Kuopio, Finla Kuopio Univ Hosp POB 1627 Kuopio Finland FIN-70211 io, Finla
Citazione:
P. Jakala et al., "Guanfacine and clonidine, alpha2-agonists, improve paired associates learning, but not delayed matching to sample, in humans", NEUROPSYCH, 20(2), 1999, pp. 119-130

Abstract

The present study compares the effects of two alpha2-agonists, clonidine (0.5, 2, and 5 mu g/kg, PO) and guanfacine (7 and 29 mu g/kg, PO) in young healthy volunteers on their performance in visual paired associates learning(PAL) and delayed matching to sample (DMTS) visual short-term recognition memory tests. In the PAL test, clonidine 2 and guanfacine 29 mu g/kg improved the subjects' performance. In the DMTS test, clonidine at 5 mu g/kg delay-dependently impaired performance accuracy, and at 2 and 5 mu g/kg it alsoslowed responses. Guanfacine had no effect on DMTS test performance. Clonidine 5 and guanfacine 29 mu g/kg equally increased subjective feelings of sedation and reduced blood pressure. The results suggest that both clonidineand guanfacine facilitated PAL learning by improving "frontal strategies,"but only clonidine disrupted "mnemonic processing" decreasing DMTS accuracy. The greater selectivity of guanfacine for alpha2A-adrenoceptor subtype may explain the different profile of action of the drugs. [Neuropsychopharmacology 20: 119-130, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:28:24