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Titolo:
Intravenous immunoglobulin for the treatment of acquired myasthenia gravis
Autore:
Howard, JF;
Indirizzi:
Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 eurol, Chapel Hill, NC 27599 USA Univ N Carolina, Lab Myasthenia Gravis Res, Chapel Hill, NC 27599 USA UnivN Carolina Chapel Hill NC USA 27599 s Res, Chapel Hill, NC 27599 USA
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 51, anno: 1998, supplemento:, 5
pagine: S30 - S36
SICI:
0028-3878(199812)51:6<S30:IIFTTO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-GLOBULIN THERAPY; HEPATITIS-C; ASEPTIC-MENINGITIS; ACETYLCHOLINE-RECEPTOR; IMMUNE GLOBULIN; PLASMA-EXCHANGE; MOTOR ENDPLATE; T-CELLS; IGG; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Howard, JF Univ599Carolina, Dept Neurol, 751 Clin Sci Bldg,CB 7025, ChapelHill, NC 27 Univ N Carolina 751 Clin Sci Bldg,CB 7025 Chapel Hill NC USA 27599
Citazione:
J.F. Howard, "Intravenous immunoglobulin for the treatment of acquired myasthenia gravis", NEUROLOGY, 51(6), 1998, pp. S30-S36

Abstract

Acquired myasthenia gravis (MG) is an autoimmune disorder characterized byexertional fatigue and weakness that is made worse with activity and improved with rest, only to recur with the resumption of activity. The pathologyresults fi om an antibody-mediated attack to several different epitopes ofthe acetylcholine receptor (AChR) complex. The consensus of an expert panel is that intravenous immunoglobulin (IVIg) is effective in reversing myasthenic weakness. Although the mechanism of action is not known, it is likelythat there is a downregulation of antibody production. IVIg appears to have a role as an acute treatment intervention in rapidly progressive weaknessor as a chronic maintenance therapy when all other treatment modalities have failed. Its response is similar to but slower than the response of plasma exchange (PE), but it offers advantages when therapeutic apheresis is notavailable or when vascular access is problematic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:53:27