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Titolo:
Transactivation by expression of the hepatitis B virus X protein with an inducible system
Autore:
Azizan, A; Cong, YS; Shain, K; Tsai, SC; Yao, YL; Olashaw, N; Seto, E;
Indirizzi:
Univ2S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 3361 Univ S Florida Tampa FL USA 33612 itt Canc Ctr & Res Inst, Tampa, FL 3361 Univ S Florida, Coll Med, Dept Med Microbiol & Immunol, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 icrobiol & Immunol, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Biochem & Mol Biol, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 Biochem & Mol Biol, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Anat, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 oll Med, Dept Anat, Tampa, FL 33612 USA
Titolo Testata:
MOLECULAR BIOLOGY REPORTS
fascicolo: 4, volume: 25, anno: 1998,
pagine: 231 - 236
SICI:
0301-4851(199811)25:4<231:TBEOTH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; HUMAN IMMUNODEFICIENCY VIRUS; NF-KAPPA-B; MAMMALIAN-CELLS; TRANS-ACTIVATION; GENE; INFECTION; DNA;
Keywords:
hepatitis B virus; inducible expression system; transcriptional activation; X protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Seto, E Univ2S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 3361 Univ S Florida Tampa FL USA 33612 Ctr & Res Inst, Tampa, FL 3361
Citazione:
A. Azizan et al., "Transactivation by expression of the hepatitis B virus X protein with an inducible system", MOL BIOL RP, 25(4), 1998, pp. 231-236

Abstract

We describe here the conditional expression of the hepatitis B virus X protein using the inducible system controlled by a tet-responsive promoter. Induction of the X protein in Rat-2 fibroblasts activated transcription from a heterologous gene promoter and stimulated the DNA-binding activity of NFkB. The ability to produce this biologically active X protein in a stable cell line will accelerate the elucidation of the function and mechanisms of Xand eventually help us understand the role of X in natural viral infectionand carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:05:54