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Titolo:
Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2052922 and age-specific fertility rates of women withepilepsy
Autore:
Wallace, H; Shorvon, S; Tallis, R;
Indirizzi:
Univrp,ll London, Natl Hosp Neurol & Neurosurg, Inst Neurol, Epilepsy Res G Univ Coll London London England WC1N 3BG rg, Inst Neurol, Epilepsy Res G UnivdManchester, Hope Hosp, Dept Geriatr Med, Salford M6 8HD, Lancs, Englan Univ Manchester Salford Lancs England M6 8HD alford M6 8HD, Lancs, Englan
Titolo Testata:
LANCET
fascicolo: 9145, volume: 352, anno: 1998,
pagine: 1970 - 1973
SICI:
0140-6736(199812)352:9145<1970:AIAPRO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Shorvon, S Univrp,ll London, Natl Hosp Neurol & Neurosurg, Inst Neurol, Epilepsy Res G Univ Coll London London England WC1N 3BG urol, Epilepsy Res G
Citazione:
H. Wallace et al., "Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2052922 and age-specific fertility rates of women withepilepsy", LANCET, 352(9145), 1998, pp. 1970-1973

Abstract

Background There are no data on prevalence or incidence of treated epilepsy, and no data on fertility of women with epilepsy from an unselected UK population. Methods We used the General Practice Research Database to ascertain the incidence and prevalence of people with treated epilepsy in an unselected population of 2 052 922 people in England and Wales, and also age-specific fertility rates. We defined period prevalence of treated epilepsy as the number of people with epilepsy taking an antiepileptic drug per 100 000 people during 1995. The incidence of treated epilepsy was defined as the number of new cases of treated epilepsy per 100 000 people during the same period. Wecalculated fertility rates among women with treated epilepsy between 1991 and 1995 and compared these rates with the population rates for England andWales in 1993. Findings The period prevalence of treated epilepsy in 1995 was 5.15 per 1000 people (95% CI 5.05-5.25). The prevalence was lower in children (age 5-9years 3.16 [2.86-3.48]; 10-14 years 4.05 [3.70-4.42]), and higher in olderpeople (65-69 years 6.01 [5.50-6.57]; 70-74 years 6.53 [5.97-7.14]; 75-79 years 7.39 [6.73-8.11]); 80-84 years 7.54 [6.78-8.39]; 85 years and older 7.73 [6.98-8.66]. The incidence of treated epilepsy was 80.8 per 100 000 people (76.9-84.7). The incidence was lower in children (5-9 years 63.2 [50.5-79.1]; 10-14 years 53.8 [42.4-68.31) and higher in older people (65-69 years 85.9 [68.5-107.3]; 70-74 years 82.8 [65.0-105.2]; 75-79 years 114.5 [116.9-179.2]; 80-84 years 159 [125.2-202.6]; greater than or equal to 85 years 135.4 [100.4-178.7]). Fertility was lower among women with treated epilepsy, with an overall rate of 47.1 livebirths per 1000 women aged 15-44 per year (42.3-52.2), compared with a national rate of 62.6 in the same age-group. The standardised fertility ratios were significantly lower between the ages of 25 and 39 years in women with epilepsy (p<0.001). Interpretation Compared with previous studies, we found that the incidenceof epilepsy was higher in elderly people and lower in children. The prevalence rates also increase with age. Women aged 25-39 years with treated epilepsy have significantly lower fertility rates than those in the general population. Research is needed to identify any potentially preventable causes for the low fertility rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:34:11