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Titolo:
Chronic K depletion inhibits renal brush border membrane Na/sulfate cotransport
Autore:
Markovich, D; Wang, HM; Puttaparthi, K; Zajicek, H; Rogers, T; Murer, H; Biber, J; Levi, M;
Indirizzi:
Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 St Lucia, Qld 4072, Australia Univ Zurich, Inst Physiol, Zurich, Switzerland Univ Zurich Zurich Switzerland urich, Inst Physiol, Zurich, Switzerland Jarvis Christian Coll, Hawkins, TX USA Jarvis Christian Coll Hawkins TX USA vis Christian Coll, Hawkins, TX USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Texas Dallas TX USA , SW Med Ctr, Dept Internal Med, Dallas, TX USA Dept Vet Affairs Med Ctr, Dallas, TX USA Dept Vet Affairs Med Ctr Dallas TX USA t Affairs Med Ctr, Dallas, TX USA
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 1, volume: 55, anno: 1999,
pagine: 244 - 251
SICI:
0085-2538(199901)55:1<244:CKDIRB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-KIDNEY; INORGANIC SULFATE; MESSENGER-RNA; TRANSPORT; LOCALIZATION; EXPRESSION; OOCYTES; PROTEIN; NASI-1;
Keywords:
dietary K; growth and development; proximal tubule; vasoconstriction; renal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Markovich, D Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 4072, Australia
Citazione:
D. Markovich et al., "Chronic K depletion inhibits renal brush border membrane Na/sulfate cotransport", KIDNEY INT, 55(1), 1999, pp. 244-251

Abstract

Background. The purpose of this study was to determine if dietary potassium (K) deficiency regulates renal proximal tubular sodium gradient-dependentsulfate transport (Na/S-i cotransport) in the rat and, furthermore, determine if the regulation takes place at the level of the recently cloned Na/Sicotransport system (NaSi-1). Methods and Results. Rats treated chronically (seven days) with a K-deficient diet had a significant decrease in serum S-i levels and an increase in fractional excretion of ultrafilterable S-i, which paralleled a significantdecrease in brush border membrane (BBM) Na/S-i cotransport activity. The decrease in BBM Na/S-i cotransport activity was associated with decreases inBBM NaSi-1 protein and renal cortical NaSi-1 mRNA abundance. Ln addition, in Xenopus oocytes injected with mRNA from kidney cortex slices of K-deficient rats, there was a significant reduction in the induced Na/S-i cotransport, whereas there was no alteration in L-leucine uptake, suggesting that inK-deficient rats, there is a specific decrease in functional: mRNA encoding the NaSi-1 mRNA. Conclusion. These findings indicate that chronic K deficiency leads to a reduction in serum S-i levels and an increase fractional excretion of S-i, and reduces S-i reabsorption by down-regulating the expression of the proximal tubular Na/S-i-1 cotransporter protein and mRNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:43:08