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Titolo:
Differential effects of N-methyl-D-aspartate receptor blockade on eticlopride-induced immediate early gene expression in the medial and lateral striatum
Autore:
Keefe, KA; Adams, AC;
Indirizzi:
UnivAUtah, Sch Pharm, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 US Univ Utah Salt Lake City UT USA 84112 oxicol, Salt Lake City, UT 84112 US
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 287, anno: 1998,
pagine: 1076 - 1083
SICI:
0022-3565(199812)287:3<1076:DEONRB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; NMDA RECEPTORS; GLUTAMATE RECEPTORS; SUBUNIT COMPOSITION; DENDRITIC SPINES; BASAL GANGLIA; DOPAMINE; NEURONS; RAT; IFENPRODIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Keefe, KA UnivLakeh, Sch Pharm, Dept Pharmacol & Toxicol, 30 S 2000 E,Room211, Salt Univ Utah 30 S 2000 E,Room 211 Salt Lake City UT USA 84112 Salt
Citazione:
K.A. Keefe e A.C. Adams, "Differential effects of N-methyl-D-aspartate receptor blockade on eticlopride-induced immediate early gene expression in the medial and lateral striatum", J PHARM EXP, 287(3), 1998, pp. 1076-1083

Abstract

The function of striatopallidal neurons is regulated by N-methy-D-aspartate (NMDA) and dopamine D2 receptors. Previous studies show that immediate early gene induction by D2 receptor blockade is suppressed by NMDA receptor antagonists. Because the pharmacology of NMDA receptors depends on the incorporation of different NR2 subunits and NR2 subunits show regional and cellular differences in their expression in striatum, our study examined whetherdifferent NMDA receptor antagonists would have differential effects on eticlopride-induced immediate early gene expression in striatum. Male Sprague-Dawley rats were pretreated with vehicle, CGS 19755, MK-801 or ifenprodil. Rats then received injections of eticlopride and were killed 40 min later. In situ hybridization histochemistry was used to determine the expression of c-fos and zif268 in the striatum. Eticlopride increased immediate early gene expression in striatum, with the increase generally being greater in lateral than in medial striatum. Pretreatment with each of the NMDA receptor antagonists dose-dependently decreased the expression of the immediate early genes. This suppression of eticlopride-induced gene expression was significant only in the medial-central aspect of striatum. Although there was a trend toward suppression of the gene induction in lateral striatum, it did not reach statistical significance and was not typically dose dependent. Thedata suggest that different types of NMDA receptor antagonists do not exert differential effects on D2 dopamine receptor-mediated function in the striatum. In addition, the data indicate that eticlopride-induced gene expression in the striatum is not uniformly dependent on NMDA receptor activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:37:24