Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modulatory effect of environmental stimuli on the susceptibility to amphetamine sensitization: A dose-effect study in rats
Autore:
Browman, KE; Badiani, A; Robinson, TE;
Indirizzi:
Univ Michigan, Dept Psychol, Biopsychol Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 hol Program, Ann Arbor, MI 48109 USA Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 287, anno: 1998,
pagine: 1007 - 1014
SICI:
0022-3565(199812)287:3<1007:MEOESO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; BEHAVIORAL SENSITIZATION; ROTATIONAL BEHAVIOR; ENDURING CHANGES; PSYCHOMOTOR; ANIMALS; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, TE UnivMIichigan, Dept Psychol, Biopsychol Program, 525 E Univ St, Ann Arbor, Univ Michigan 525 E Univ St Ann Arbor MI USA 48109 Ann Arbor,
Citazione:
K.E. Browman et al., "Modulatory effect of environmental stimuli on the susceptibility to amphetamine sensitization: A dose-effect study in rats", J PHARM EXP, 287(3), 1998, pp. 1007-1014

Abstract

In previous studies the repeated administration of 0.5 to 1.0 mg/kg of amphetamine i.v. failed to induce psychomotor sensitization if the drug was administered to animals living in the test environment (at home). The same doses did induce sensitization if animals were transported to the test environment for each drug treatment. The purpose of the present experiment was todetermine the extent to which this effect of environment is dose dependent. Rats either lived in test cages or were transported from the animal colony to test cages where they received an i.v. infusion of one of five doses of amphetamine (0.125, 0.5, 1.0, 4.0 or 8.0 mg/kg) or saline each day for 5 consecutive days. Rotational behavior was used as an index of psychomotor activation. After a 6-day drug-free period all animals were challenged with 0.5 mg/kg of amphetamine to determine the pretreatment dose necessary to induce sensitization. The effect of the drug-treatment environment was to shift the dose-effect curve for the induction of sensitization, such that significantly lower doses were necessary to induce sensitization when amphetamine was given in a novel environment. With high doses, however, sensitization occurred regardless of environmental condition. It is concluded that the circumstances surrounding drug administration can powerfully modulate the ability of psychostimulants to induce sensitization, but this effect is dosedependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:31:22