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Titolo:
Dopamine modulates the responsivity of mediodorsal thalamic cells recordedin vitro
Autore:
Lavin, A; Grace, AA;
Indirizzi:
Univ Pittsburgh, Ctr Neurosci, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh, Ctr Neurosci, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 24, volume: 18, anno: 1998,
pagine: 10566 - 10578
SICI:
0270-6474(199812)18:24<10566:DMTROM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION; ACUTELY DISSOCIATED NEURONS; PREFRONTAL CORTICAL-NEURONS; RAT STRIATAL NEURONS; NIGRA ZONA COMPACTA; SLOW-WAVE SLEEP; SUBSTANTIA NIGRA; BASAL GANGLIA; RELAY NEURONS;
Keywords:
thalamus; dopamine; low-threshold spikes; K+ conductances; D1 agonist; D2 agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Lavin, A Univ,Pittsburgh, Ctr Neurosci, Dept Neurosci, 446 Crawford Hall, Pittsburgh Univ Pittsburgh 446 Crawford Hall Pittsburgh PA USA 15260 tsburgh
Citazione:
A. Lavin e A.A. Grace, "Dopamine modulates the responsivity of mediodorsal thalamic cells recordedin vitro", J NEUROSC, 18(24), 1998, pp. 10566-10578

Abstract

The mediodorsal thalamic nucleus (MD) receives convergent inputs from subcortical limbic structures that overlap with a dopaminergic (DA) innervation. In this study, we describe the effects of DA agonists on the basal and evoked electrophysiological activity of identified thalamic cells of rats recorded in vitro. Administration of the DI agonist SFK 38393 (10 mu M) did not produce a clear effect on the physiological properties of the thalamic cells recorded. In contrast, bath administration of the D2 agonist quinpirole(10 mu M) resulted in an enhancement of membrane excitability, facilitation of the occurrence of low-threshold spikes (LTSs), and changes in the resting membrane potential of the thalamic cells tested. The quinpirole-mediated responses were reversed by administration of the D2 antagonist haloperidol. Results from experiments performed with different [K+] and K+ channel blockers suggest that the effects of quinpirole are mediated at least in partby changes in K+ conductances. The results from this study suggest that DAcan modulate the excitabitity of thalamic cells and in turn may influence the way that the thalamocortical system integrates information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:00:55