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Titolo:
Administration of dexamethasone up-regulates protein kinase C activity andthe expression of gamma and epsilon protein kinase C isozymes in the rat brain
Autore:
Dwivedi, Y; Pandey, GN;
Indirizzi:
Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Inst Psychiat, Chicago, IL 60612 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 72, anno: 1999,
pagine: 380 - 387
SICI:
0022-3042(199901)72:1<380:AODUPK>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHORBOL ESTER BINDING; BETA-ADRENERGIC RECEPTORS; CEREBRAL-CORTEX; DEPRESSION; HIPPOCAMPUS; ADRENALECTOMY; SEROTONIN-2; PITUITARY; DECREASES; CORTISOL;
Keywords:
cortex; dexamethasone; glucocorticoids; hippocampus; hypothalamic-pituitary-adrenal axis; rat brain; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Pandey, GN Univ60612nois, Dept Psychiat, Inst Psychiat, 1601 W Taylor St, Chicago, IL Univ Illinois 1601 W Taylor St Chicago IL USA 60612 Chicago, IL
Citazione:
Y. Dwivedi e G.N. Pandey, "Administration of dexamethasone up-regulates protein kinase C activity andthe expression of gamma and epsilon protein kinase C isozymes in the rat brain", J NEUROCHEM, 72(1), 1999, pp. 380-387

Abstract

Altered hypothalamic-pituitary-adrenal (HPA) function (increased plasma coitisol level) has been shown to be associated with mood and behavior. Protein kinase C (PKC), an important component of the phosphatidylinositol signal transduction system, plays a major role in mediating various physiological functions. The present study investigates the effects of acute (single) and repeated (10-day) administrations of 0.5 or 1.0 mg/kg doses of dexamethasone (DEX), a synthetic glucocorticoid, on B-max and K-D of [H-3]phorbol 12,13-dibutyrate ([H-3]PDBu) binding, PKC activity, and protein expression ofPKC isozymes alpha, beta, gamma, delta, and epsilon in the membrane and the cytosolic fractions of rat cortex and hippocampus. It was observed that repeated administration of 1.0 mg/kg DEX for 10 days caused a significant increase in B-max of [H-3]PDBu binding to PKC, in PKC activity, and in expressed protein levels of the gamma and epsilon isozymes in both the cytosolic and the membrane fractions of the cortex and the hippocampus, whereas a lower dose of DEX (0.5 mg/kg for 10 days) caused these changes only in the hippocampus. On the other hand, a single administration of DEX (0.5 or 1.0 mg/kg) had no significant effect on PKC in the cortex or in the hippocampus. These results suggest that alterations in HPA function from repeated administration of glucocorticoids may modulate PKC-mediated functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:24:44