Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats
Autore:
Tonai, T; Taketani, Y; Ueda, N; Nishisho, T; Ohmoto, Y; Sakata, Y; Muraguchi, M; Wada, K; Yamamoto, S;
Indirizzi:
Natl Zentsuji Hosp, Dept Orthoped Surg, Kagawa 7650001, Japan Natl Zentsuji Hosp Kagawa Japan 7650001 oped Surg, Kagawa 7650001, Japan Natl Zentsuji Hosp, Clin Res Inst, Kagawa 7650001, Japan Natl Zentsuji Hosp Kagawa Japan 7650001 Res Inst, Kagawa 7650001, Japan Univ Tokushima, Sch Med, Dept Biochem, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 d, Dept Biochem, Tokushima 770, Japan Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 77101 t, Tokushima 77101, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 72, anno: 1999,
pagine: 302 - 309
SICI:
0022-3042(199901)72:1<302:PIOIIC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MESSENGER-RNA; INDUCIBLE CYCLOOXYGENASE; CEREBRAL-ISCHEMIA; BRAIN; EXPRESSION; GLUCOCORTICOIDS; PROSTAGLANDINS; MECHANISMS; INCREASE;
Keywords:
spinal cord injury; cyclooxygenase; interleukin-1; prostaglandin; thromboxane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tonai, T Natlapantsuji Hosp, Dept Orthoped Surg, 2-1-1 Sen Yu Cho, Kagawa 7650001, J Natl Zentsuji Hosp 2-1-1 Sen Yu Cho Kagawa Japan 7650001 0001, J
Citazione:
T. Tonai et al., "Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats", J NEUROCHEM, 72(1), 1999, pp. 302-309

Abstract

A standardized compression injury of rat spinal cord brought about a time-dependent biphasic production of thromboxane A(2) (detected as thromboxane B-2) and prostaglandin I-2 (detected as 6-ketoprostaglandin F-1 alpha). Thromboxane B-2 was predominant during the first 1 h, whereas the 8-ketoprostaglandin F-1 alpha level exceeded that of thromboxane B-2 at 8 h postinjury. As examined by inhibitor experiments and northern blotting, cyclooxygenase-l was responsible for the first phase, and cyclooxygenase-2 was involved in the second phase. On compression injury the levels of interleukin-1 alphaand -1 beta detected as mRNA and protein increased and peaked at 2-4 h. Injection of exogenous interleukin-1 alpha into the spinal cord resulted in an increase of cyclooxygenase-2 mRNA content and a predominant production ofB-ketoprostaglandin F-1 alpha resembling the second phase of eicosanoid production. Concomitantly, extravascular migra tion of polymorphonuclear leukocytes was enhanced after the interleukin-1 alpha injection. These cells together with vascular endothelial cells and glial cells were stained positively with an anti-cyclooxygenase-2 antibody. The results suggest that the immediate eicosanoid synthesis after spinal cord injury was due to the constitutive cyclooxygenase-l and the delayed synthesis of eicosanoids was attributable to the induction of cyclooxygenase-2 mediated by interleukin-1 alpha.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:17:32