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Titolo:
Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(di-n-propylamino)tetralin: Microdialysis and autoradiographic studies in rat brain
Autore:
Casanovas, JM; Vilaro, MT; Mengod, G; Artigas, F;
Indirizzi:
CSIC,nInst Invest Biomed Barcelona, Dept Neurochem, E-08034 Barcelona, Spai CSIC Barcelona Spain E-08034 na, Dept Neurochem, E-08034 Barcelona, Spai
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 72, anno: 1999,
pagine: 262 - 272
SICI:
0022-3042(199901)72:1<262:DROSS5>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE; IN-VIVO; 5-HYDROXYTRYPTAMINE RELEASE; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; BINDING SITES; 8-OH-DPAT; AUTORECEPTORS; IPSAPIRONE; INHIBITION; NUCLEI;
Keywords:
serotonin 5-HT1A receptors; 5-hydroxytryptamine release; anxiety; depression; dorsal raphe nucleus; frontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Artigas, F CSIC,8034t Invest Biomed Barcelona, Dept Neurochem, Jordi Girona 18-26, E-0 CSIC Jordi Girona 18-26 Barcelona Spain E-08034 ona 18-26, E-0
Citazione:
J.M. Casanovas et al., "Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(di-n-propylamino)tetralin: Microdialysis and autoradiographic studies in rat brain", J NEUROCHEM, 72(1), 1999, pp. 262-272

Abstract

Single treatment with the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and alnespirone(S-20499) reduces the extracellular 5-HT concentration (5-HText) in the rat midbrain and forebrain, Given the therapeutic potential of selective 5-HT1A agonists in the treatment of affective disorders, we have examined the changes in 5-HT1A receptors induced by 2-week minipump administration of alnespirone (0.3 and 3 mg/kg/day) and 8-OH-DPAT (0.1 and 0.3 mg/kg/day). The treatment with alnespirone did not modify baseline 5-HText but significantlyattenuated the ability of 0.3 mg/kg s.c. alnespirone to reduce 5-HText in the dorsal raphe nucleus (DRN) and frontal cortex. In contrast, the abilityof 8-OH-DPAT (0.025 and 0.1 mg/kg s.c.) to reduce 5-HText in both areas was unchanged by 8-OH-DPAT pretreatment. Autoradiographic analysis revealed asignificant reduction of [H-3]8-OH-DPAT and [H-3]WAY-100635 {H-3-labeled N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide . 3HCl} binding to somatodendritic 5-HT1A receptors (but not to postsynaptic 5-HT1A receptors) of rats pretreated with alnespirone but not with8-OH-DPAT. In situ hybridization analysis revealed no change of the density of the mRNA encoding the 5-HT1A receptors in the DRN after either treatment. These data indicate that continuous treatment for 2 weeks with alnespirone, but not with 8-OH-DPAT, causes a functional desensitization of somatodendritic 5-HT1A receptors controlling 5-HT release in the DRN and frontal cortex.

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Documento generato il 16/07/20 alle ore 18:59:05