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Titolo:
IMPAIRMENT OF PUPILLARY RESPONSES AND OPTOKINETIC NYSTAGMUS IN THE MGLUR6-DEFICIENT MOUSE
Autore:
IWAKABE H; KATSUURA G; ISHIBASHI C; NAKANISHI S;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT BIOL SCI,SAKYO KU KYOTO 606 JAPAN KYOTO UNIV,FAC MED,DEPT BIOL SCI,SAKYO KU KYOTO 606 JAPAN SHIONOGI & CO LTD,SHIONOGI RES LABS SHIGA 52034 JAPAN
Titolo Testata:
Neuropharmacology
fascicolo: 2, volume: 36, anno: 1997,
pagine: 135 - 143
SICI:
0028-3908(1997)36:2<135:IOPRAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; RETINAL BIPOLAR CELLS; LATERAL GENICULATE-NUCLEUS; 2-AMINO-4-PHOSPHONOBUTYRIC ACID; OLFACTORY-BULB; VISUAL-SYSTEM; LIGHT REFLEX; RAT RETINA; CHANNELS; CONDUCTANCE;
Keywords:
METABOTROPIC GLUTAMATE RECEPTOR; GENE TARGETING; VISUAL ON/OFF SEGREGATION; VISUAL CONTRAST; PUPILLARY RESPONSE; OPTOKINETIC NYSTAGMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Iwakabe et al., "IMPAIRMENT OF PUPILLARY RESPONSES AND OPTOKINETIC NYSTAGMUS IN THE MGLUR6-DEFICIENT MOUSE", Neuropharmacology, 36(2), 1997, pp. 135-143

Abstract

Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly at the postsynaptic site of retinal ON-bipolar cells. Ablation of mGluR6 in the ON-bipolar cells bygene targeting results in a loss of ON responses but unchanged OFF responses in visual transmission. Thus, mGluR6 is essential for inducingON responses. The aims of this study are analyses of visual responsiveness and possible visual dysfunction in mGluR6-deficient mice. We report here that mGluR6-deficient mice have unaltered locomotor activity in a daily light-dark cycle and exhibit light-stimulated induction of Fos immunoreactivity in the suprachiasmatic nucleus. These findings indicate that mGluR6-deficient mice are capable of responding to light stimulation. The mGluR6 deficiency, however, markedly reduces the sensitivity of pupillary responses to light stimulus and severely impairs the ability to drive optokinetic nystagmus ill response to visual contrasts. This study thus demonstrates that mGluR6 contributes to discrimination of visual contrasts. (C) 1997 Elsevier Science Ltd.

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Documento generato il 28/03/20 alle ore 23:43:03