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Titolo:
Differential pharmacology of newer antidepressants
Autore:
DeVane, CL;
Indirizzi:
Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Sci, Charleston, SC 29425 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 59, anno: 1998, supplemento:, 20
pagine: 85 - 93
SICI:
0160-6689(1998)59:<85:DPONA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HYDROXYLATION IN-VITRO; HUMAN LIVER-MICROSOMES; EXTRAPYRAMIDAL SYMPTOMS; FLUOXETINE; TOLERABILITY; SERTRALINE; 5-HYDROXYTRYPTAMINE; ENANTIOMERS; NEFAZODONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: DeVane, CL MedAUniv S Carolina, Dept Psychiat, 171 Ashley Ave, Charleston,SC 29425 US Med Univ S Carolina 171 Ashley Ave Charleston SC USA 29425 5 US
Citazione:
C.L. DeVane, "Differential pharmacology of newer antidepressants", J CLIN PSY, 59, 1998, pp. 85-93

Abstract

New antidepressants have become available for clinical use in the 1990s. Before this decade, the drugs available to treat depression consisted essentially of lithium, the monoamine oxidase inhibitors, and tricyclic antidepressants. Trazodone and bupropion, introduced in the mid-1980s, were the first major departures from the pharmacology of the tricyclics. Following the introduction in 1988 of the first serotonin selective reuptake inhibitor (SSRI) in the United Slates, the options have expanded and now include four SSRIs (fluoxetine, sertraline, paroxetine, fluvoxamine), nefazodone, venlafaxine, and mirtazapine. Citalopram and reboxetine are expected to be available by the end of the decade. These newer drugs possess a variety of pharmacological characteristics that are relevant to the choice of an antidepressant for clinical use. This review summarizes some of the major pharmacokinetic and pharmacodynamic similarities and differences among these drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:22:02