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Titolo:
Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines
Autore:
Kubo, K; Matsuzaki, Y; Kato, A; Terai, S; Okita, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 14, anno: 1999,
pagine: 41 - 46
SICI:
1019-6439(199901)14:1<41:AEOVOH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEOXYRIBONUCLEOSIDE-TRIPHOSPHATE IMBALANCE; DOUBLE STRAND BREAKS; MOUSE FM3A CELLS; 3,4-DIHYDRO-6-<4-(3,4-DIMETHOXYBENZOYL)-1-PIPERAZINYL>-2(1H)-QUINOLINONE VESNARI; HEPATOMA-CELLS; P53 GENE; DEATH; APOPTOSIS; INDUCTION; GROWTH;
Keywords:
vesnarinone; antitumor effect; hepatocellular carcinoma; apoptosis; nucleotide synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kubo, K Yamaguchi7558505,ch Med, Dept Internal Med 1, 1144 Kogushi, Ube, Yamaguchi Yamaguchi Univ 1144 Kogushi Ube Yamaguchi Japan 7558505 Yamaguchi
Citazione:
K. Kubo et al., "Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines", INT J ONCOL, 14(1), 1999, pp. 41-46

Abstract

Vesnarinone, a quinolinone derivative, induces apoptosis and differentiation in some tumor cell lines. We examined the antitumor effect of vesnarinone on three human hepatocellular carcinoma (HCC) cell lines. Vesnarinone suppressed the proliferation of all three HCC cell lines, but did not induce apoptosis and differentiation. Vesnarinone has also been reported to inhibitboth nucleoside and nucleobase transport. Concomitant administration of vesnarinone and a de novo nucleotide synthesis inhibitor potentiated the growth-inhibitory effect of vesnarinone on HCC cells. Vesnarinone may be usefulas a new biochemical modulator of anticancer agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:27:06