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Titolo:
Ragweed allergy: Correlation between skin reactivity and in vitro complement activation
Autore:
Dervaderics, M; Hidvegi, T; Schmidt, B; Fust, G; Varga, L;
Indirizzi:
Hungarian Acad Sci, Res Grp Membrane Biol & Immunopathol, Budapest, Hungary Hungarian Acad Sci Budapest Hungary l & Immunopathol, Budapest, Hungary Semmelweis Univ Med, Dept Pulmonol, H-1125 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1125 ol, H-1125 Budapest, Hungary Hungarian Acad Sci, Natl Inst Haematol & Immunol, Budapest, Hungary Hungarian Acad Sci Budapest Hungary ematol & Immunol, Budapest, Hungary Semmelweis Univ Med, Dept Med 3, H-1125 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1125 3, H-1125 Budapest, Hungary
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 2-3, volume: 64, anno: 1998,
pagine: 119 - 123
SICI:
0165-2478(199812)64:2-3<119:RACBSR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE-RELEASE; MEDIATOR RELEASE; DOUBLE-BLIND; MAST-CELLS; HAY-FEVER; IMMUNOTHERAPY; EXTRACTS; C3A; GENERATION; SYMPTOMS;
Keywords:
complement; allergy; ragweed; IgE; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fust, G Hungarian Acad Sci, Res Grp Membrane Biol & Immunopathol, Budapest, Hungary Hungarian Acad Sci Budapest Hungary nopathol, Budapest, Hungary
Citazione:
M. Dervaderics et al., "Ragweed allergy: Correlation between skin reactivity and in vitro complement activation", IMMUNOL LET, 64(2-3), 1998, pp. 119-123

Abstract

Recently we have reported on several observations which indicate that allergen-induced complement activation contributes to the development of the symptoms of ragweed allergy. In the present paper a new finding that supportsthis assumption is summarized. In 48 ragweed-allergic patients individual skin reactivity to ragweed allergen extract (RWA) was assessed using dilution skin prick testing. Sera of these patients were incubated with 20, 100, and 400 U/ml RWA and generation of two complement activation products, alternative pathway C3-convertase (C3bBbP) and terminal pathway activation complex (C5b-9) was measured by ELISA methods. A strong positive correlation (Spearman correlation coefficient r = 0.495, P = 0.0004, and r = 0.454, P = 0.0012, respectively) was found between individual skin reactivity to RWA and C3bBbP generation induced by 20 and 100 A allergological units/ml (U/ml) RWA. This finding further supports the role of complement activation products in the aggravation of the basic IgE-mediated immunopathology of ragweed allergy. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:48:01