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Titolo:
Lisinopril decreases plasma free testosterone in male hypertensive patients and increases sex hormone binding globulin in female hypertensive patients
Autore:
Koshida, H; Takeda, R; Miyamori, I;
Indirizzi:
Kohseiren Takaoka Hosp, Dept Internal Med 2, Takaoka, Toyama 9338555, Japan Kohseiren Takaoka Hosp Takaoka Toyama Japan 9338555 Toyama 9338555, Japan Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Fukui Med Sch, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Sch Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan
Titolo Testata:
Hypertension research
fascicolo: 4, volume: 21, anno: 1998,
pagine: 279 - 282
SICI:
0916-9636(199812)21:4<279:LDPFTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II RECEPTORS; SERUM; CELLS; WOMEN;
Keywords:
lisinopril; testosterone; estradiol; sex hormone binding globulin; essential hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Koshida, H Kohseirenmaakaoka Hosp, Dept Internal Med 2, 5-10 Eiraku Cho, Takaoka, Toya Kohseiren Takaoka Hosp 5-10 Eiraku Cho Takaoka Toyama Japan 9338555
Citazione:
H. Koshida et al., "Lisinopril decreases plasma free testosterone in male hypertensive patients and increases sex hormone binding globulin in female hypertensive patients", HYPERTENS R, 21(4), 1998, pp. 279-282

Abstract

The effect of an angiotensin-converting enzyme inhibitor, lisinopril, on gonadal hormones was assessed in 20 patients with essential hypertension. A daily dose of 5 to 20 mg of lisinopril was administered for 6 mo. In male patients, the free testosterone (f-T) concentration decreased significantly (before, 13.8 +/- 2.4 pg/ml; after, 9.9 +/- 1.5 pg/ml: mean +/- SEM, p < 0.05), whereas the plasma total testosterone (T), estradiol (E-2), and sex hormone binding globulin (SHBG) concentrations were not significantly affected. Lisinopril had no effect on plasma T, f-T, or E-2 concentrations in female patients, but significantly increased the plasma SHBG concentration (before, 48.0+/-6.1 nmol/l; after, 62.7 +/- 6.7 nmol/l: p < 0.01), The results of this preliminary study suggest that lisinopril affects plasma f-T and SHBG concentrations. The clinical implications of lisinopril-induced changes in plasma f-T and SHBG concentrations remain to be clarified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:47:46