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Titolo:
Renal 11 beta-hydroxysteroid dehydrogenase in genetically salt-sensitive hypertensive rats
Autore:
Takeda, Y; Inaba, S; Furukawa, K; Miyamori, I;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 32, anno: 1998,
pagine: 1077 - 1082
SICI:
0194-911X(199812)32:6<1077:R1BDIG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC-ARTERIES; DAHL RAT; ALDOSTERONE SYNTHASE; POTENT INHIBITORS; LOCALIZATION; MUTATIONS; TYPE-2; GENE; 11-ALPHA-HYDROXYPROGESTERONE; 11-BETA-HYDROXYPROGESTERONE;
Keywords:
glucocorticoids; mineralocorticoids; rats, Dahl; kidney; hypertension, essential; sodium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y KanazawashikawaSch Med, Dept Internal Med 2, 13-1 Takara Machi, Kanazawa, I Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 920 a, I
Citazione:
Y. Takeda et al., "Renal 11 beta-hydroxysteroid dehydrogenase in genetically salt-sensitive hypertensive rats", HYPERTENSIO, 32(6), 1998, pp. 1077-1082

Abstract

Renal 11 beta-hydroxysteroid dehydrogenase II (11 beta-HSDII) converts glucocorticoids into inactive metabolites and plays an important role in controlling blood pressure and sodium retention. To examine whether this enzyme may be involved in the pathophysiology of salt-sensitive hypertension, we determined 11 beta-HSDII activity and mRNA levels in the blood vessel and kidney of Dahl Iwai salt-sensitive (DS) rats and Dahl Iwai salt-resistant (DR) rats. Urinary free corticosterone:free Il-dehydrocorticosterone ratio wasmeasured to estimate renal 11 beta-HSD activity. Vascular 11 beta-HSDII activity was expressed as percent conversion of [H-3]corticosterone to [H-3]11-dehydrocorticosterone in homogenized mesenteric arteries. 11 beta-HSDII mRNA was estimated with the use of competitive polymerase chain reaction (PCR), Renal 11 beta-HSDII activity and mRNA levels were significantly decreased in 8- and 12-week-old high salt DS rats compared with DR, Sprague-Dawley(SD), or low salt DS rats of the same age. Decreased 11 beta-HSDII activity and mRNA levels in mesenteric arteries were observed in 8- and 12-week-old high salt DS rats. Urinary excretion of 11 beta-HSDII inhibitory factors was measured by inhibition of enzyme activity in microsomes from human kidney. The urinary inhibitors were significantly increased in 8- and 12-week-old high salt DS rats compared with DR, SD, or low salt DS rats of the same age. There were no significant differences in 11 beta-HSDII activity and mRNA levels in mesenteric arteries and kidney or in urinary inhibitors between 4-week-old DS, DR, and SD rats. These results indicate that 11 beta-HSDIImay play a role in salt sensitivity and development of hypertension in theDS rat.

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Documento generato il 30/11/20 alle ore 09:58:34