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Titolo:
Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea
Autore:
Narkiewicz, K; Pesek, CA; Kato, M; Phillips, BG; Davison, DE; Somers, VK;
Indirizzi:
Univ Iowa, Dept Internal Med, Div Cardiovasc, Coll Med, Iowa City, IA 52242 Univ Iowa Iowa City IA USA 52242 ardiovasc, Coll Med, Iowa City, IA 52242 Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA USA Univ Iowa Iowa City IA USA harm, Div Clin & Adm Pharm, Iowa City, IA USA
Titolo Testata:
HYPERTENSION
fascicolo: 6, volume: 32, anno: 1998,
pagine: 1039 - 1043
SICI:
0194-911X(199812)32:6<1039:BCOSNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLD PRESSOR TEST; ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; SENSITIVITY; POPULATION; HUMANS; AGE;
Keywords:
autonomic nervous system; sympathetic nervous system; sleep apnea; blood pressure; heart rate; baroreceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Somers, VK UnivaIowa, Dept Internal Med, Div Cardiovasc, Coll Med, 200 Hawkins Dr, Iow Univ Iowa 200 Hawkins Dr Iowa City IA USA 52242 Hawkins Dr, Iow
Citazione:
K. Narkiewicz et al., "Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea", HYPERTENSIO, 32(6), 1998, pp. 1039-1043

Abstract

Patients with obstructive sleep apnea are at increased risk for hypertension. The mechanisms underlying this increased risk are not known. We tested the hypothesis that obstructive sleep apnea, independent of factors such ashypertension, obesity, and age, is characterized by impairment of baroreflex sensitivity, We measured muscle sympathetic nerve activity (MSNA) and heart rate responses to activation and deactivation of baroreceptors in newlydiagnosed, never treated, normotensive patients with obstructive sleep apnea. These responses were compared with those obtained in healthy control subjects closely matched for age, body mass index, and blood pressure. Heart rate and MSNA changes during infusion of phenylephrine (baroreceptor activation) were similar in the control subjects and patients with sleep apnea. Infusion of nitroprusside (baroreceptor deactivation) elicited similar decreases in mean arterial pressure (MAP) but lesser MSNA increases in patients with sleep apnea than in control subjects, Calculation of Delta MSNA/Delta MAP ratio revealed that baroreflex regulation of sympathetic activity for similar blood pressure changes was diminished in patients with sleep apnea in comparison to normal control subjects (P=0.01), However, increases in heart rate during nitroprusside infusion were comparable in both groups. Sympathetic, blood pressure and heart rate responses to the cold presser test were also similar in the 2 groups, Our results indicate that normotensive patients with sleep apnea have a selective impairment of the sympathetic response to baroreceptor deactivation but not to baroreceptor activation or to the cold presser test. The impairment of baroreflex sympathetic modulation in patients with sleep apnea is not accompanied by any impairment of baroreflex control of heart rate.

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Documento generato il 01/04/20 alle ore 09:28:57