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Titolo:
Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver
Autore:
Servillo, G; Della Fazia, MA; Sassone-Corsi, P;
Indirizzi:
Univulaire,Pasteur Strasbourg 1, INSERM, CNRS, Inst Genet & Biol Mol & Cell Univ Louis Pasteur Strasbourg 1 Illkirch Graffenstaden France F-67404 ll
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 23, volume: 12, anno: 1998,
pagine: 3639 - 3643
SICI:
0890-9369(199812)12:23<3639:TFCCTT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DESENSITIZATION; MESSENGER-RNA EXPRESSION; CYCLIC-AMP; CELL-CYCLE; GENE-EXPRESSION; RAT-LIVER; CAMP; PHOSPHORYLATION; INDUCTION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sassone-Corsi, P Univulaire,Pasteur Strasbourg 1, INSERM, CNRS, Inst Genet& Biol Mol & Cell Univ Louis Pasteur Strasbourg 1 Illkirch GraffenstadenFrance F-67404
Citazione:
G. Servillo et al., "Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver", GENE DEV, 12(23), 1998, pp. 3639-3643

Abstract

The liver regenerates upon partial hepatectomy (PH) as terminally differentiated hepatocytes undergo a tremendous proliferative process. CREM gene expression is powerfully induced during liver regeneration. We show that cellproliferation is significantly reduced upon PH in CREM-/- mice. There is areduction in DNA synthesis, in the number of mitosis and of phosphorylatedhistone H3-positive cells. The post-PH proliferation peak is delayed by 10hr, indicating an altered hepatocyte cell cycle. Expression of cyclins A, B, D1, E, and cdc2, of c-fos and tyrosine aminotransferase is deregulated. CREM mutation results in delayed S-phase entry, impairing the synchronization of proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:25:48