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Titolo:
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease
Autore:
Mikolajczyk-Pawlinska, J; Travis, J; Potempa, J;
Indirizzi:
Jagiellonian,Univ, Inst Mol Biol, Dept Immunol & Microbiol, PL-31120 Krakow Jagiellonian Univ Krakow Poland PL-31120 ol & Microbiol, PL-31120 Krakow Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Biochem & Mol Biol, Athens, GA 30602 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 440, anno: 1998,
pagine: 282 - 286
SICI:
0014-5793(199812)440:3<282:MOIABG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC FACTOR; BACTEROIDES GINGIVALIS; CYSTEINE PROTEINASES; TISSUE DESTRUCTION; ACTIVATING FACTOR; HOST-DEFENSE; CYTOKINES; LEUKOCYTE; EXPRESSION; CHEMOKINES;
Keywords:
proteinase; interleukin-8; neutrophil activation; chemokine; periodontitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Potempa, J Jagiellonian3,niv, Inst Mol Biol, Dept Immunol & Microbiol, Al Mickiewicza Jagiellonian Univ Al Mickiewicza 3 Krakow Poland PL-31120 icza
Citazione:
J. Mikolajczyk-Pawlinska et al., "Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease", FEBS LETTER, 440(3), 1998, pp. 282-286

Abstract

Gingipains are the major cysteine proteinases synthesized by Porphyromonasgingivalis which, in soluble form, are able to initially convert IL-8 (77 amino acid residues) to a more potent species truncated at the amino terminus, followed by slow degradation and destruction of chemokine biological activity, In contrast, the same enzymes when associated with bacterial outer-membrane blebs (vesicles), instantly degrade this chemokine. This division of enhancing and inactivating activity between soluble and membrane-bound gingipains can cause the compartmentalization of pro- and anti-inflammatory reactions to distal and proximal positions from bacterial plaque, respectively, which may explain why, despite the massive neutrophil accumulation at periodontitis sites, there is no elimination of infection. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:23:14