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Titolo:
Intercellular distribution of cytogenetic changes detected by chromosome painting in irradiated blood lymphocytes of cancer patients
Autore:
Arutyunyan, R; Martus, P; Neubauer, S; Birkenhake, S; Dunst, J; Sauer, R; Gebhart, E;
Indirizzi:
Yerevan State Univ, Yerevan 375049, Armenia Yerevan State Univ Yerevan Armenia 375049 Univ, Yerevan 375049, Armenia Univangen,gen Nurnberg, Inst Med Informat Biometry & Epidemiol, D-91054 Erl Univ Erlangen Nurnberg Erlangen Germany D-91054 & Epidemiol, D-91054 Erl Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univermanygen Nurnberg, Clin & Polyclin Radiat Therapy, D-91054 Erlangen, G Univ Erlangen Nurnberg Erlangen Germany D-91054 apy, D-91054 Erlangen, G Univ Halle Wittenberg, Clin Radiat Therapy, D-06110 Halle, Germany Univ Halle Wittenberg Halle Germany D-06110 rapy, D-06110 Halle, Germany
Titolo Testata:
EXPERIMENTAL ONCOLOGY
fascicolo: 3-4, volume: 20, anno: 1998,
pagine: 223 - 228
SICI:
0204-3564(199809/12)20:3-4<223:IDOCCD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IONIZING-RADIATION; ABERRATIONS; EXPOSURE;
Keywords:
cancer patients; radiation therapy; culture of lymphocytes; chromosome painting; chromosomal aberrations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Arutyunyan, R Yerevan State Univ, Yerevan 375049, Armenia Yerevan State Univ Yerevan Armenia 375049 375049, Armenia
Citazione:
R. Arutyunyan et al., "Intercellular distribution of cytogenetic changes detected by chromosome painting in irradiated blood lymphocytes of cancer patients", EXP ONCOL, 20(3-4), 1998, pp. 223-228

Abstract

A three-colour chromosome in situ suppression (CISS) hydridization technique (chromosome painting) was used to analyse X-ray-induced chromosome aberrations in peripheral lymphocytes of 83 cancer patients who were assigned to(N = 34) or had just undergone radiation therapy (N = 49). The imperical intercellular distribution of chromosomal aberrations was compared with Poisson distribution and geometric distribution. The impact of complex aberrations on this distributions allowed to discern patients with a high radiationsensitivity from those with an average clinical reaction to therapeutic irradiation. In the group of non-exposed patients, the low mean level of aberrations fitted both distributions in the majority of cases. In contrast, inthe group of previously irradiated patients, the geometric distribution inmost cases fitted more variants. After an in vitro irradiation of the lymphocytes both groups showed a great interindividual variation between the patients concerning the means and the fit to the distributions, despite similar mean values. The distribution of break points generating the observed spectrum of aberrations, except their variants with low level of mean, did even less fit either of the examined distributions. The use of parameters notonly concerning the average number of aberrations or breaks but also theirintercellular patterns improved the separation of the previously exposed from the non-exposed, as well as average-reacting patients from radiosensitive patients. The data presented have also documented the high power of the chromosome painting technique in detecting and analysing long-term clastogenic effects as well as complex rearrangements. Examination of these patterns by use of goodness-of-fit tests is expected to offer additional information for discriminating radiosensitive cancer patients.

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Documento generato il 29/09/20 alle ore 00:36:59