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Titolo:
An evaluation of the influence of devazepide and CCK-8S on the intact and resected rat liver
Autore:
Ohlsson, B; Rehfeld, JF; Axelson, J;
Indirizzi:
Univ Lund Hosp, Dept Surg, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Hosp, Dept Surg, S-22185 Lund, Sweden Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 Biochem, DK-2100 Copenhagen, Denmark
Titolo Testata:
EUROPEAN SURGICAL RESEARCH
fascicolo: 6, volume: 30, anno: 1998,
pagine: 378 - 384
SICI:
0014-312X(199811/12)30:6<378:AEOTIO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ RECEPTOR ANTAGONIST; FOOD-INTAKE; GROWTH; REGENERATION; SECRETION; DIVERSION; MALNUTRITION; MECHANISM; INFUSION; PEPTIDES;
Keywords:
liver; liver resection; CCK; devazepide; trophic effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ohlsson, B Univ Lund Hosp, Dept Surg, S-22185 Lund, Sweden Univ Lund HospLund Sweden S-22185 Surg, S-22185 Lund, Sweden
Citazione:
B. Ohlsson et al., "An evaluation of the influence of devazepide and CCK-8S on the intact and resected rat liver", EUR SURG RE, 30(6), 1998, pp. 378-384

Abstract

Background: Recently, it has been shown that infusion of the CCK-A receptor antagonist devazepide induced proliferation of hepatocytes and bile duct epithelium in the rat liver. The aim of this study was to further evaluate the influence of devazepide and sulfated cholecystokinin-8 (CCK-8S) on the intact rat liver and rat liver after resection. Methods: In the first experiment, either saline or devazepide was injected subcutaneously twice daily to rats for 18 and 36 h and 3 and 7 days. In the second experiment, a 70% liver resection was followed by infusion of either DMSO, devazepide, saline or CCK-8S for 2 or 7 days. Prior to sacrifice, all rats received 1 mCi/kg of tritiated thymidine intraperitoneally. The liver was excised and the contents of protein, DNA and water and incorporation of tritiated thymidine were measured. Results: Intermittent injections of devazepide increased the liver protein conte nt after 36 h, followed by a decrease after 7 days. The weight, DNA content or cell proliferation was not affected. Two days after liver resection hyperCCKemia was evoked, which was less prominent after 7 days. Devazepide lowered the plasma concentration of CCK, while the infusion of CCK-8S resulted in extremely high concentrations at both time points. The DNA synthesis measured by thymidine incorporation was increased by devazepide on day 2., whereas the weight or protein and DNA contents of the liverwere not influenced. CCK-8S infusion decreased the body and liver weight throughout the study, and the protein and DNA contents after 7 days. Conclusions: Intermittent devazepide treatment did not affect the intact liver. Devazepide increased the DNA synthesis 2 days after liver resection but was without other influences on the liver regeneration, CCK-8S induced decreasedbody weight with ensuing negative effects on the liver regeneration. Neither devazepide nor CCK seem to be of any therapeutic use after liver resection or liver failure.

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Documento generato il 28/09/20 alle ore 17:13:13