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Titolo:
LFA-1 mediated cell adhesion induces G0-G1 transition of human T lymphocytes in vitro
Autore:
Bossi, G; Bottone, MG; Pellicciari, C;
Indirizzi:
Univ Pavia, CNR, Dipartimento Biol Anim, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 artimento Biol Anim, I-27100 Pavia, Italy Univ Pavia, CNR, Ctr Studio Istochim, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Ctr Studio Istochim, I-27100 Pavia, Italy Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England
Titolo Testata:
EUROPEAN JOURNAL OF HISTOCHEMISTRY
fascicolo: 4, volume: 42, anno: 1998,
pagine: 277 - 285
SICI:
1121-760X(1998)42:4<277:LMCAIG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATION-RELATED ANTIGEN; CYCLE PROGRESSION; NUCLEAR-PROTEIN; ANTIBODY KI-67; EXPRESSION; LOCALIZATION; RESPONSES; INTEGRINS; RECEPTORS; MOLECULE;
Keywords:
LFA-1 integrin receptor; Ki-67 nuclear antigen; cell proliferation; T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bossi, G UnivyPavia, CNR, Dipartimento Biol Anim, Piazza Bot 10, I-27100 Pavia, Ital Univ Pavia Piazza Bot 10 Pavia Italy I-27100 I-27100 Pavia, Ital
Citazione:
G. Bossi et al., "LFA-1 mediated cell adhesion induces G0-G1 transition of human T lymphocytes in vitro", EUR J HIST, 42(4), 1998, pp. 277-285

Abstract

Proliferation of mature T lymphocytes requires antigenic stimulation of the T cell receptor/CD3 complex (TCR/CD3) and an additional signal provided by different accessory molecules, including the leukocyte adhesion receptor LFA-1. We have used a cytochemical approach to analyse the effect of LFA-1 stimulation, either alone or in association with TCR/CD3 triggering. A dualparameter cytometric analysis of DNA content versus Ki-67 positivity allowed progression throughout the cell cycle to be monitored. Engagement of LFA-I alone was able to initiate the intracellular events necessary for Ki-67 expression (marking G0-G1 transition) in a fraction of the T cell population but was not sufficient to induce the transit into S-phase. Cross-linking of both LFA-1 and CD3 was required for DNA synthesis to occur. These data confirm LFA-1 as an important costimulatory molecule of TCR-mediated T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:31:30