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Titolo:
Paediatric and hereditary aspects of chronic pancreatitis
Autore:
Dodge, JA;
Indirizzi:
Singleton Hosp, Dept Child Hlth, Swansea SA2 8QA, W Glam, Wales Singleton Hosp Swansea W Glam Wales SA2 8QA wansea SA2 8QA, W Glam, Wales
Titolo Testata:
DIGESTION
, volume: 59, anno: 1998, supplemento:, 4
pagine: 49 - 59
SICI:
0012-2823(1998)59:<49:PAHAOC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE GENE; TRANSMEMBRANE CONDUCTANCE REGULATOR; INCREASED LIPID-PEROXIDATION; CYSTIC-FIBROSIS; EXOCRINE PANCREAS; PROTEIN; SECRETION; CHILDREN; RISK; DYSFUNCTION;
Keywords:
cystic fibrosis; hereditary pancreatitis; hyperlipidaemia; chronic pancreatitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Dodge, JA Singleton Hosp, Dept Child Hlth, Swansea SA2 8QA, W Glam, Wales Singleton Hosp Swansea W Glam Wales SA2 8QA 8QA, W Glam, Wales
Citazione:
J.A. Dodge, "Paediatric and hereditary aspects of chronic pancreatitis", DIGESTION, 59, 1998, pp. 49-59

Abstract

Cystic fibrosis is by far the commonest cause of chronic pancreatitis in children, but pancreatitis itself is only rarely its presenting feature. In this paper an hypothesis for the development of the pancreatic lesions is presented. Impaired activation of pancreatic proteases in the small intestine is perceived as the pivotal problem that leads to continual feedback release of cholecystokinin, thus, in effect, causing a chronic hyperstimulationpancreatitis with intra-acinar activation of zymogens and, when bicarbonate secretion falls, precipitation of 'Reg' and other proteins in the duct system. This position contrasts with that in hereditary pancreatitis in whicha mutation in the cationic trypsinogen gene leads to a form of trypsin that resists degradation by mesotrypsin and enzyme Y. A survey of the literature suggests that oxidant stress is a plausible contributor to pancreatic injury in both these diseases and in several other conditions linked with childhood pancreatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:45:52