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Titolo:
Glucagon-like peptide-1 activates the adenylyl cyclase system in rockfish enterocytes and brain membranes
Autore:
Mommsen, TP; Mojsov, S;
Indirizzi:
Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada UnivVictoria Victoria BC Canada V8W 3P6 ol, Victoria, BC V8W 3P6, Canada Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 mmunol Lab, New York, NY 10021 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 1, volume: 121, anno: 1998,
pagine: 49 - 56
SICI:
0305-0491(199809)121:1<49:GPATAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; PETROMYZON-MARINUS; AMERICAN EEL; RECEPTOR; HEPATOCYTES; PROGLUCAGON; INTESTINE; PANCREAS; FISH; EXPRESSION;
Keywords:
enterocytes; brain; membranes; GLP-1; cAMP; adenylyl cyclase; glucagon; exendin; enzymes; Sebastes caurinus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mommsen, TP Univ Victoria, Dept Biochem & Microbiol, POB 3055,MS 7077, Victoria, BC V8W Univ Victoria POB 3055,MS 7077 Victoria BC Canada V8W 3P6 V8W
Citazione:
T.P. Mommsen e S. Mojsov, "Glucagon-like peptide-1 activates the adenylyl cyclase system in rockfish enterocytes and brain membranes", COMP BIOC B, 121(1), 1998, pp. 49-56

Abstract

Glucagon-like peptide (GLP) exerts important physiological functions in fish liver, but extrahepatic sites of action and physiological roles have been largely ignored. We show here that GLP activates adenylyl cyclase in isolated brain and enterocyte membranes and increases cellular cyclic adenosinemonophosphate (cAMP) levels in isolated enterocytes of rockfish (Sebastes caurinus). Following exposure to synthetic zebrafish GLP (zf-GLP) (1 nM-1 mu M), a concentration-dependent increase in enterocyte cAMP is noted. The maximum increase in cAMP levels is observed at I mu M zf-GLP, and representsa 30% increase above control values. Exendin-4, a GLP receptor agonist in mammals, elicits a similar concentration-dependent increase in enterocyte cAMP. In contrast, norepinephrine or prostaglandin E-2 (at 1 mu M) increasedcAMP levels by 2 and 4-fold, respectively. Brain membrane adenylyl cyclaseis activated 20-40% by zf-GLP, and to a smaller extent by zf-glucagon, while exendin-4, is as effective as zf-GLP at a dose of 100 nM. These results suggest potential physiological roles of GLP in brain and intestine in piscine systems analogous to GLP-1 functions in these tissues described for mammals. (C) 1998 Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:32:24