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Titolo:
Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation
Autore:
Katoh, A; Ikeda, H; Murohara, T; Haramaki, N; Ito, H; Imaizumi, T;
Indirizzi:
Kurume Univ, Sch Med, Dept Internal Med 3, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 al Med 3, Kurume, Fukuoka 830, Japan
Titolo Testata:
CIRCULATION
fascicolo: 25, volume: 98, anno: 1998,
pagine: 2891 - 2898
SICI:
0009-7322(199812)98:25<2891:P1APAI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC FLOW VARIATIONS; ARACHIDONIC-ACID; ARTERY STENOSES; BLOOD-FLOW; AGGREGATION; LIPOXYGENASE; MECHANISMS; INHIBITORS; SELECTIN; ASPIRIN;
Keywords:
platelets; hydroxyeicosatetraenoic acid; platelet aggregation; glycoproteins thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, H Kurume830,v, Sch Med, Dept Internal Med 3, 67 Asahi Machi, Kurume, Fukuoka Kurume Univ 67 Asahi Machi Kurume Fukuoka Japan 830 rume, Fukuoka
Citazione:
A. Katoh et al., "Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation", CIRCULATION, 98(25), 1998, pp. 2891-2898

Abstract

Background-In the thrombotic process of acute coronary syndromes, the pathophysiological role of thromboxane A, via cyclooxygenase is well established; however, the role of 12-HETE via 12-lipoxygenase is little known. Therefore, we used OPC-29030, a novel specific inhibitor of 12-HETE synthesis, totest whether platelet-derived 12-HETE is involved in mediating cyclic flowvariations (CFVs) and platelet aggregation in stenosed and endothelium-injured canine coronary arteries. Methods and Results-After developing CFVs, dogs received a vehicle or OPC-29030 intravenously. Plasma and intraplatelet 12-HETE levels increased after CFVs, OPC-29030 but not vehicle reduced CFVs, which was associated with decreases in plasma and intraplatelet 12-HETE levels, Cessation of OPC-29030restored CFVs in association with increases in plasma and intraplatelet 12-HETE levels. ADP and U46619 induced ex vivo platelet 12-HETE production and aggregation. After OPC-29030 administration, the ADP- and U46619-induced increases in ex vivo platelet 12-HETE production and aggregation were inhibited significantly. Platelet aggregation was linearly correlated with platelet 12-HETE production. OPC-29030 suppressed activation of human platelet glycoprotein IIb/IIIa. Conclusions-OPC-29030 reduced intraplatelet 12-HETE levels, resulting in the inhibition of coronary thrombosis in vivo in dogs, OPC-29030 inhibited human platelet glycoprotein IIb/IIIa activation in vitro. Thus, platelet-derived 12-HETE may play an important role in mediating thrombotic process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:56:48