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Titolo:
TOTAL PARENTERAL-NUTRITION AFFECTS THE TROPHIC EFFECT OF CHOLECYSTOKININ ON THE EXOCRINE PANCREAS
Autore:
FAN BG; AXELSON J; STERNBY B; REHFELD J; IHSE I; EKELUND M;
Indirizzi:
LUND UNIV,DEPT SURG LUND SWEDEN LUND UNIV,DEPT INTERNAL MED LUND SWEDEN RIGSHOSP,DEPT CLIN BIOCHEM DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 4, volume: 32, anno: 1997,
pagine: 380 - 386
SICI:
0036-5521(1997)32:4<380:TPATTE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATICOBILIARY DIVERSION; GASTROINTESTINAL-TRACT; TIME-COURSE; A RECEPTOR; RATS; RELEASE; SECRETION; TRYPSIN; STIMULATION; ATROPHY;
Keywords:
CHOLECYSTOKININ; DEVAZEPIDE; DNA; PANCREAS; PANCREATIC ENZYMES; PANCREATICOBILIARY DIVERSION; PROTEIN; TOTAL PARENTERAL NUTRITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
B.G. Fan et al., "TOTAL PARENTERAL-NUTRITION AFFECTS THE TROPHIC EFFECT OF CHOLECYSTOKININ ON THE EXOCRINE PANCREAS", Scandinavian journal of gastroenterology, 32(4), 1997, pp. 380-386

Abstract

Background: Cholecystokinin (CCK) exerts trophic effects on the exocrine pancreas. Total parenteral nutrition (TPN) results in hypotrophy of the pancreas. The present study aimed to examine the effect of exogenous and endogenous CCK during TPN. Methods: Seventy-two Sprague-Dawley rats were orally fed or given TPN after pancreaticobiliary diversion(PBD) and were infused with CCK-8S or the CCK-receptor antagonist devazepide for 7 days. Results: Infusion of CCK and PBD caused hyperCCKemia, whereas TPN did not influence the concentration of plasma CCK. Thereduced pancreatic contents during TPN could be reversed by CCK but not by PBD. The hyperplastic response to CCK in orally fed rats was abolished during TPN. Devazepide did not influence the pancreatic variables in orally fed and TPN-treated rats. Conclusion: TPN reduces the hyperplastic response of the exocrine pancreas to CCK, and CCK reverses the hypotrophy seen during TPN. The effects of CCK on the exocrine pancreas seems to need enteral nutrition for the full expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:44:32