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Titolo:
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
Autore:
Scolding, N; Franklin, R; Stevens, S; Heldin, CH; Compston, A; Newcombe, J;
Indirizzi:
MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2SR, England MRC Cambridge England CB2 2SR r Brain Repair, Cambridge CB2 2SR, England Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 1TN, EnglandUniv Cambridge Cambridge England CB2 1TN nit, Cambridge CB2 1TN, England Univ Cambridge, Dept Vet Med, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN Med, Cambridge CB2 1TN, England Inst Neurol, Multiple Sclerosis Lab, London WC1N 3BG, England Inst NeurolLondon England WC1N 3BG erosis Lab, London WC1N 3BG, England Ludwig Inst Canc Res, S-75124 Uppsala, Sweden Ludwig Inst Canc Res Uppsala Sweden S-75124 Res, S-75124 Uppsala, Sweden
Titolo Testata:
BRAIN
, volume: 121, anno: 1998,
parte:, 12
pagine: 2221 - 2228
SICI:
0006-8950(199812)121:<2221:OPAPIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PDGF-ALPHA-RECEPTOR; CENTRAL-NERVOUS-SYSTEM; RAT OPTIC-NERVE; GROWTH-FACTOR; DEMYELINATING DISEASE; NG2 PROTEOGLYCAN; SPINAL-CORD; CELLS; EXPRESSION; REMYELINATION;
Keywords:
human oligodendrocyte progenitor; remyelination; multiple sclerosis; PDGF-alpha receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Scolding, N MRC,B2ambridge Ctr Brain Repair, Univ Forvie Site,Robinson Way, Cambridge C MRC Univ Forvie Site,Robinson Way Cambridge England CB2 2SR C
Citazione:
N. Scolding et al., "Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis", BRAIN, 121, 1998, pp. 2221-2228

Abstract

In multiple sclerosis, partial remyelination is conspicuous in many lesions, but widespread and lasting myelin repair ultimately fails as disability and handicap accumulate. Thus far, the precise identity of the cell responsible for limited spontaneous myelin repair has remained obscure. In the rodent, the proliferative oligodendrocyte progenitor is the most efficient remyelinating cell; this has now been identified in cultures prepared from normal human brain, but has proved difficult to demonstrate in situ. We adapted techniques using antibodies against the human platelet-derived growth factor-a receptor to identify oligodendrocyte progenitors in human tissue sections. Small numbers of oligodendrocyte progenitors were found in normal adult human white matter. Progenitors were also demonstrable in acute and chronic lesions from patients dying with multiple sclerosis, but with no evidence of any marked reactive increase in cell numbers. Understanding the biology of the remyelinating cell, and in particular the reason for its apparentfailure to repopulate demyelinated lesions, is important for the development of remyelination treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:58:43