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Titolo:
Lipase-catalyzed esterification of unusual substrates: Synthesis of glucuronic acid and ascorbic acid (vitamin C) esters
Autore:
Otto, RT; Bornscheuer, UT; Scheib, H; Pleiss, J; Syldatk, C; Schmid, RD;
Indirizzi:
Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany Univ Stuttgart Stuttgart Germany D-70569 hem, D-70569 Stuttgart, Germany Univ Stuttgart, Inst Biochem Engn, D-70569 Stuttgart, Germany Univ Stuttgart Stuttgart Germany D-70569 ngn, D-70569 Stuttgart, Germany
Titolo Testata:
BIOTECHNOLOGY LETTERS
fascicolo: 11, volume: 20, anno: 1998,
pagine: 1091 - 1094
SICI:
0141-5492(199811)20:11<1091:LEOUSS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
Candida antarctica; lipase; glucuronic acid; vitamin C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schmid, RD Univnytuttgart, Inst Tech Biochem, Allmandring 31, D-70569 Stuttgart, Germa Univ Stuttgart Allmandring 31 Stuttgart Germany D-70569 Germa
Citazione:
R.T. Otto et al., "Lipase-catalyzed esterification of unusual substrates: Synthesis of glucuronic acid and ascorbic acid (vitamin C) esters", BIOTECH LET, 20(11), 1998, pp. 1091-1094

Abstract

The synthesis of n-butanol and cinnamic alcohol esters of glucuronic acid and the esterification of ascorbic acid (vitamin C) with phenylbutyric acidwas performed with lipase from Candida antarctica B (CAL-B, SP435) in a mainly solid-phase system. Products were obtained in 15 to 22 % yield. Computer modelling based on the structure of CAL-B was used to elucidate the access of glucuronic acid to the catalytic site of the lipase. A fixation of glucuronic acid via H-bonds to Q157, D134 and H224 during the transition state was observed.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:31:52