Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Metal composition of human hepatic and renal metallothionein
Autore:
Orlowski, C; Piotrowski, JK;
Indirizzi:
Med Univ Lodz, Dept Toxicol Chem, PL-90151 Lodz, Poland Med Univ Lodz Lodz Poland PL-90151 t Toxicol Chem, PL-90151 Lodz, Poland
Titolo Testata:
BIOLOGICAL TRACE ELEMENT RESEARCH
fascicolo: 2, volume: 65, anno: 1998,
pagine: 133 - 141
SICI:
0163-4984(199811)65:2<133:MCOHHA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-KIDNEY CORTEX; CADMIUM-METALLOTHIONEIN; LIVER; ZINC; COPPER; MERCURY; RATS; NEPHROTOXICITY; BINDING; TISSUES;
Keywords:
humans; metallothionein; cadmium; zinc; copper;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Piotrowski, JK Med Univ Lodz, Dept Toxicol Chem, Muszynskiego 1, PL-90151 Lodz, Poland Med Univ Lodz Muszynskiego 1 Lodz Poland PL-90151 , Poland
Citazione:
C. Orlowski e J.K. Piotrowski, "Metal composition of human hepatic and renal metallothionein", BIOL TR EL, 65(2), 1998, pp. 133-141

Abstract

This article is based on data on the levels of metals (Cd, Zn, Cu) and metallothionein (MT) determined radiochemically with Hg-203 in renal cortex and liver of 137 autopsy cases. From this number, for 23 cases, the gel filtration of the cytoplasmic fraction of the organs was performed. The molar content of metals in the MT fraction (Sephadex G-50) amounted to46.9, 50.2, and 2.0% for Cd, Zn, and Cu in renal cortex, respectively, andto 8.3, 83.6, and 9.1% for Cd, Zn, and Cu in the liver, respectively. In parallel with the increase of Cd and MT in renal cortex, increasing saturation was found of the MT fraction by Cd, occurring at the expense of Zn and Cu. Equimolar amounts of Cd and Zn in the MT fraction are found at Cd level of 0.5 mu mol Cd/g wet wt of renal cortex. In the liver, analogous dependency (elevation of %Zn, depression of %Cd and %Cu) were observed in relation to Zn and MT levels in this organ. The basic level of Zn (not bound with MT) was estimated at 0.5 mu mol/g for both renal cortex and Liver. A deficit of non-MT Zn in kidneys is proposed as an alternative mechanism of toxic Cd action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:52:19