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Titolo:
Motor activation by amphetamine infusion into nucleus accumbens core and shell subregions of rats differentially sensitive to dopaminergic drugs
Autore:
West, CHK; Boss-Williams, KA; Weiss, JM;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 98, anno: 1999,
pagine: 155 - 165
SICI:
0166-4328(199901)98:1<155:MABAII>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; CUE-DIRECTED BEHAVIORS; JAW MOVEMENTS; 6-HYDROXYDOPAMINE LESIONS; EXTRACELLULAR DOPAMINE; NMDA-ANTAGONIST; D-2 RECEPTORS; STRIATUM; INJECTIONS;
Keywords:
amphetamine; depression; locomotor activity; midbrain dopamine; nucleus accumbens core and shell; selective breeding; SwHi/SwLo rats; swim test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: West, CHK Georgia06ental Hlth Inst, Room 504-N,1256 Briarcliff Rd NE, Atlanta, GA 303 Georgia Mental Hlth Inst Room 504-N,1256 Briarcliff Rd NE Atlanta GA USA 30306
Citazione:
C.H.K. West et al., "Motor activation by amphetamine infusion into nucleus accumbens core and shell subregions of rats differentially sensitive to dopaminergic drugs", BEH BRA RES, 98(1), 1999, pp. 155-165

Abstract

Selective breeding based on activity in a swim test has been used to produce lines of rats that show a high level of activity in the swim test (Swim High-active (SwHi) rats) and a low level of activity in the swim test (SwimLow-active (SwLo) rats). Previous studies have indicated that dopamine (DA) function is enhanced in SwHi rats and reduced in SwLo rats; a principal finding was that SwLo rats showed much smaller increases in ambulatory activity after systemic administration of amphetamine than did SwHi or non-selected rats. In light of the importance of the nucleus accumbens (NAC) in amphetamine-induced activity, the present study investigated whether DA function in NAC differs in SwHi and SwLo rats. Amphetamine was infused bilaterallyinto either the core or shell subregion of NAG, and ambulation or swim test activity was then measured. In SwLo rats, infusion of amphetamine (0.2-2.0 mu g) into either NAC core or shell produced moderate increases in ambulation. In SwHi rats, infusion of amphetamine into NAC shell produced similarmoderate increases in ambulation, but infusion into the core produced markedly larger dose-related increases in ambulation. In the swim test, infusion of amphetamine (1.0 mu g) increased activity by affecting the dominant behavior of each line; i.e. struggling increased in SwHi rats and floating decreased in SwLo rats, with large effects seen in both lines with infusion into either NAC core or shell. These results support the idea that the distinct behavioral characteristics of SwHi and SwLo rats are mediated in part by differences in NAC-DA function. (C) 1999 Elsevier Science B.V. All rightsreserved.

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Documento generato il 27/01/20 alle ore 01:19:42