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Titolo:
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
Autore:
Takagi, N; Mihara, M; Moriya, Y; Nishimoto, N; Yoshizaki, K; Kishimoto, T; Takeda, Y; Ohsugi, Y;
Indirizzi:
Chugaianharmaceut Co Ltd, Fuji Gotemba Res Labs, Gotemba, Shizuoka 412, Jap Chugai Pharmaceut Co Ltd Gotemba Shizuoka Japan 412 ba, Shizuoka 412, Jap Osaka Univ, Osaka, Japan Osaka Univ Osaka JapanOsaka Univ, Osaka, Japan
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 12, volume: 41, anno: 1998,
pagine: 2117 - 2121
SICI:
0004-3591(199812)41:12<2117:BOIRAJ>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; IL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Chugaimba,rmaceut Co Ltd, Fuji Gotemba Res Labs, 135 Komakado 1 Chome, Gote Chugai Pharmaceut Co Ltd 135 Komakado 1 Chome Gotemba Shizuoka Japan 412
Citazione:
N. Takagi et al., "Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis", ARTH RHEUM, 41(12), 1998, pp. 2117-2121

Abstract

Objective. To clarify the role of interleukin-6 (IL-6) in the pathogenesisof collagen-induced arthritis (CIA). Methods. CIA was induced by immunizing twice at a 3-week interval with bovine type II collagen (CII) emulsified with complete adjuvant, Rat anti-mouse IL-6 receptor (anti-IL-6R) monoclonal antibody MR16-1 or isotype-matched control antibody KH-5 was then injected once intraperitoneally, Symptoms ofarthritis were evaluated with a visual scoring system, and serum anti-CII antibody and IL-6 levels were measured by enzyme-linked immunosorbent assay. In addition, the CII responsiveness of splenic lymphocytes from mice withCIA was examined. Results, In mice with CIA, excess production of IL-6 in sera was observed within 24 hours after the first CII immunization, and then rapidly decreased. Serum IL-6 increased again beginning 14 days after immunization, in conjunction,vith the onset of arthritis. When MR16-1 was injected immediately after immunization with CII, it inhibited the development of arthritis in a dose-dependent manner. Furthermore, MR16-1-treated mice exhibited lower serum levels of IgG anti-CII antibody and reduced responsiveness of lymphocytes to CII, This suppressive effect was observed when MR16-1 was injected on day 0 or 3, but not when injected on day 7 or 14. Conclusion. IL-6 produced after CII immunization appears to play an essential role in the immunity to CII, and anti-IL-6R antibody reduces the development of CIA by suppressing IL-6 signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:56:11