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Titolo:
Quantitative analysis of human serum albumin drug interactions using reversed-phase and ion-exchange liquid chromatography
Autore:
Hanai, T; Miyazaki, R; Kinoshita, T;
Indirizzi:
Inst Pasteur 5F, Hlth Res Fdn, Sakyo Ku, Kyoto 606, Japan Inst Pasteur 5FKyoto Japan 606 Hlth Res Fdn, Sakyo Ku, Kyoto 606, Japan Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 108, Japan Kitasato Univ Tokyo Japan 108 harmaceut Sci, Minato Ku, Tokyo 108, Japan
Titolo Testata:
ANALYTICA CHIMICA ACTA
fascicolo: 1-3, volume: 378, anno: 1999,
pagine: 77 - 82
SICI:
0003-2670(19990104)378:1-3<77:QAOHSA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING;
Keywords:
acidic drugs; albumin-drug interaction; modified Hummer-Dryer method; reversed-phase liquid chromatography; ion-exchange liquid chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Hanai, T Inst Pasteur 5F, Hlth Res Fdn, Sakyo Ku, Kyoto 606, Japan Inst Pasteur 5F Kyoto Japan 606 Fdn, Sakyo Ku, Kyoto 606, Japan
Citazione:
T. Hanai et al., "Quantitative analysis of human serum albumin drug interactions using reversed-phase and ion-exchange liquid chromatography", ANALYT CHIM, 378(1-3), 1999, pp. 77-82

Abstract

A new Liquid chromatographic system was developed to measure protein-drug binding affinity indirectly and evaluated using log nK values of acidic drugs measured by a modified Hummer-Dryer method using purified human serum albumin. The retention factors of acidic drugs were measured in two reversed-phases and an ion-exchange liquid chromatography. The bonded phases were butyl, phenylpropyl and guanidino phases, and their retention factors were measured in sodium phosphate buffer of pH 7.5. The combined retention factorswere correlated with the measured log nK values; the correlation coefficient was 0.948. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:59:00