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Titolo:
Proton MR spectroscopic findings correspond to neuropsychological functionin traumatic brain injury
Autore:
Friedman, SD; Brooks, WM; Jung, RE; Hart, BL; Yeo, RA;
Indirizzi:
UnivANew Mexico, Hlth Sci Ctr, Ctr Non Invas Diag, Albuquerque, NM 87131 US Univ New Mexico Albuquerque NM USA 87131 s Diag, Albuquerque, NM 87131 US Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA Univ New MexicoAlbuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA Univ New Mexico, Dept Radiol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 adiol, Albuquerque, NM 87131 USA
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 10, volume: 19, anno: 1998,
pagine: 1879 - 1885
SICI:
0195-6108(199811/12)19:10<1879:PMSFCT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; SEVERE HEAD-INJURY; DIFFUSE AXONAL INJURY; QUANTIFICATION; QUANTITATION; METABOLITES; PREDICTION; EXPERIENCE; SPECTRA; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, WM Univuerque,xico, Hlth Sci Ctr, Ctr Non Invas Diag, 1201 Yale Blvd NE, Albuq Univ New Mexico 1201 Yale Blvd NE Albuquerque NM USA 87131 lbuq
Citazione:
S.D. Friedman et al., "Proton MR spectroscopic findings correspond to neuropsychological functionin traumatic brain injury", AM J NEUROR, 19(10), 1998, pp. 1879-1885

Abstract

BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) causes substantial irreversible damage to neurons. Our aim was to investigate whether proton MR spectroscopic measures of diffuse cellular integrity were related to neuropsychological dysfunction after TBI,METHODS: Twelve patients with TBI (mean, 53 +/- 23 days postinjury) and 14control subjects were included in the study using paired MR spectroscopy and neuropsychological assessment. N-acetylaspartate (NAA), creatine, and choline were measured in normal-appearing occipitoparietal white and occipital gray matter using short-echo quantitative spectroscopy. A composite measure of neuropsychological function was calculated from z-scored individual tests probing the major functional domains commonly impaired after head trauma. RESULTS: Patients with TBI displayed reduced NAA in white matter and elevated choline in gray matter, suggestive of neuronal injury and inflammation,respectively. NAA and creatine in white and gray matter were significantlyassociated with composite neuropsychological function and many individual neuropsychological tests. Gray matter choline, although abnormal, was not related to neuropsychological function,CONCLUSION: The concordance between neurometabolic levels and behavioral function supports the hypothesis that diffuse axonal injury is an important contributor to brain dysfunction after TBI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:32:31