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Titolo:
Apoptotic cell death in Kikuchi's disease: A TEM study
Autore:
Iguchi, H; Sunami, K; Yamane, H; Konishi, K; Takayama, M; Nakai, Y; Nakagawa, T; Shibata, S; Nishimura, K;
Indirizzi:
Osaka City Univ, Sch Med, Dept Otolaryngol, Abeno Ku, Osaka 5458585, JapanOsaka City Univ Osaka Japan 5458585 ngol, Abeno Ku, Osaka 5458585, Japan Izumi City Hosp, Osaka, Japan Izumi City Hosp Osaka JapanIzumi City Hosp, Osaka, Japan Wakakusa Daiichi Hosp, Dept Otolaryngol, Osaka, Japan Wakakusa Daiichi Hosp Osaka Japan Hosp, Dept Otolaryngol, Osaka, Japan Yodogawa Christian Hosp, Dept Otolaryngol, Osaka, Japan Yodogawa ChristianHosp Osaka Japan osp, Dept Otolaryngol, Osaka, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 1998, supplemento:, 538
pagine: 250 - 253
SICI:
0001-6489(1998):<250:ACDIKD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIOCYTIC NECROTIZING LYMPHADENITIS; PLASMACYTOID T-CELLS; FUJIMOTO DISEASE; LYMPH-NODE; INVOLVEMENT; MONOCYTES;
Keywords:
apoptosis; apoptotic bodies; CD4; CD8; histiocyte; histiocytic necrotizing lymphadenitis; Kikuchi-Fujimoto disease; pathogenesis; plasmacytoid monocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Iguchi, H Osakaakaty Univ, Sch Med, Dept Otolaryngol, Abeno Ku, 1-5-7 Asahi Machi, Os Osaka City Univ 1-5-7 Asahi Machi Osaka Japan 5458585 Machi, Os
Citazione:
H. Iguchi et al., "Apoptotic cell death in Kikuchi's disease: A TEM study", ACT OTO-LAR, 1998, pp. 250-253

Abstract

The pathogenesis of Kikuchi's disease (Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis) remains unclear. However, some previous studies have suggested that a disorder in cellular immunity is responsible for this disease, and apoptotic cell death appears to be the principal finding in the histogenesis of this disease. In the present study, a lymph node froma female patient with Kikuchi's disease was examined by transmission electron microscopy (TEM). TEM revealed specific morphological features of apoptotic cells, such as nuclear chromatin condensation and fragmentation along the nuclear membrane with intact organelles, and the presence of histiocytes phagocytosing karyorrhectic debris (apoptotic bodies) in areas affected by Kikuchi's disease. Although neither the role nor the trigger of apoptosisin Kikuchi's disease has been clearly determined, our findings show that apoptotic cell death clearly plays a role in the pathogenesis of Kikuchi's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:45:32