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Titolo:
Local substances regulating cochlear blood flow
Autore:
Konishi, K; Yamane, H; Iguchi, H; Takayama, M; Nakagawa, T; Sunami, K; Nakai, Y;
Indirizzi:
Osaka City Univ, Sch Med, Dept Otolaryngol, Abeno Ku, Osaka 5458585, JapanOsaka City Univ Osaka Japan 5458585 ngol, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 1998, supplemento:, 538
pagine: 40 - 46
SICI:
0001-6489(1998):<40:LSRCBF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; NITRIC-OXIDE; STIMULATION; GANGLION; ARTERY;
Keywords:
circulation; nitric oxide; prostaglandin I-2; stria vascularis; tropomyosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Konishi, K Osakakaity Univ, Sch Med, Dept Otolaryngol, Abeno Ku, 1-5-7 Asahimachi, Osa Osaka City Univ 1-5-7 Asahimachi Osaka Japan 5458585 achi, Osa
Citazione:
K. Konishi et al., "Local substances regulating cochlear blood flow", ACT OTO-LAR, 1998, pp. 40-46

Abstract

The regulation of cochlear lateral wall blood flow was investigated in rats using histochemistry, immunohistochemistry and transmission electron microscopy. The contractile protein, tropomyosin (TM) was localized in the pericyte around the vessels of spiral ligament but little was seen around strial capillaries. Prostaglandin I-2 (PGI(2)) is a vasodilatory substance produced by PGI(2) synthase (PGI(2)S), which is present in the endothelium of the vessels of spiral ligament but not much is present around strial capillaries. Endthelial nitric oxide synthase (eNOS) was present in the endotheliumof both the vessels of spiral ligament and strial capillaries. These findings indicate that the blood flow of the cochlear lateral wall is regulated mainly in the spiral ligament by locally produced substances and that strial blood flow is not significantly regulated by pericytes responsible for enlargement or constriction of capillaries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:53:59