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Titolo:
Cycloheximide blocks the toxic effect of streptomycin on guinea pig vestibular hair cells
Autore:
Nakagawa, T; Yamane, H; Takayama, M; Sunami, K; Nakai, Y;
Indirizzi:
Yodogawa330032,ian Hosp, Dept Otorhinolaryngol, Higashiyodogawa Ku, Osaka 5 Yodogawa Christian Hosp Osaka Japan 5330032 Higashiyodogawa Ku, Osaka 5 Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Osaka 545, Japan Osaka City Univ Osaka Japan 545 Dept Otorhinolaryngol, Osaka 545, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 1998, supplemento:, 538
pagine: 36 - 39
SICI:
0001-6489(1998):<36:CBTTEO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-SYNTHESIS; NEURONAL DEATH; INNER-EAR; ACTINOMYCIN-D; RNA-SYNTHESIS; 2 MODES; APOPTOSIS; INHIBITORS; ACTIVATION;
Keywords:
apoptosis; guinea pig; protein synthesis inhibitor; sensory epithelial cell; vestibule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, T YodogawaAwaji,tian Hosp, Dept Otorhinolaryngol, Higashiyodogawa Ku, 2-9-26 Yodogawa Christian Hosp 2-9-26 Awaji Osaka Japan 5330032 9-26
Citazione:
T. Nakagawa et al., "Cycloheximide blocks the toxic effect of streptomycin on guinea pig vestibular hair cells", ACT OTO-LAR, 1998, pp. 36-39

Abstract

Apoptosis has been suggested to be a predominant cell death process for streptomycin-induced degeneration of vestibular hair cells. However, the biochemical aspects of this have not been studied. The purpose of this study was to examine the biochemical aspects of apoptosis of vestibular hair cells caused by streptomycin. Cycloheximide is a widely used protein synthesis inhibitor in studies of apoptosis. We therefore investigated cycloheximide effects on degeneration of vestibular hair cells following streptomycin applications. Supplements of cycloheximide significantly prevented DNA fragmentation in hair cell nuclei and reduced the loss of hair cells. This suggests that cpcloheximide possibly inhibits apoptosis of hair cells and attenuatesstreptomycin-induced degeneration of the vestibular epithelium.

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Documento generato il 02/12/20 alle ore 08:11:19