Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of amino acids in cochlear degeneration: Morphological changes in cochlear outer hair cells following glutamate application
Autore:
Sunami, K; Yamane, H; Konishi, K; Iguchi, H; Nakagawa, T; Shibata, S; Takayama, M; Nakai, Y;
Indirizzi:
Osakaapany Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, Osaka 5458585, J Osaka City Univ Osaka Japan 5458585 laryngol, Abeno Ku, Osaka 5458585, J Yodogawa Christian Hosp, Dept Otorhinolaryngol, Osaka, Japan Yodogawa Christian Hosp Osaka Japan Dept Otorhinolaryngol, Osaka, Japan Wakakusa Daiichi Hosp, Dept Otorhinolaryngol, Osaka, Japan Wakakusa Daiichi Hosp Osaka Japan , Dept Otorhinolaryngol, Osaka, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 1998, supplemento:, 538
pagine: 22 - 25
SICI:
0001-6489(1998):<22:ROAAIC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENTAMICIN OTOTOXICITY; INNER-EAR; APOPTOSIS; TOXICITY; DEATH; LOCALIZATION; ASPARTATE; ISCHEMIA;
Keywords:
cell death; cochlea; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sunami, K Osakai,ity Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, 1-4-3Asahi Mach Osaka City Univ 1-4-3 Asahi Machi Osaka Japan 5458585 sahi Mach
Citazione:
K. Sunami et al., "Role of amino acids in cochlear degeneration: Morphological changes in cochlear outer hair cells following glutamate application", ACT OTO-LAR, 1998, pp. 22-25

Abstract

Glutamate is an excitatory neurotransmitter in the cochlea and has toxic effects on the organ of Corti in various pathological conditions. The toxic effects of glutamate have not been determined in detail. In this study, We examined morphological changes in the organ of Corti of guinea pigs following local application of glutamate. Morphological changes were noted in outer hair cells. Degeneration of outer hair cells was found 24 h after glutamate treatment. The extent of degeneration depended on exposure time. Inner hair cells did not exhibit any degeneration. In addition, no degenerative changes were detected in nerve endings attached to hair cells. These findingssuggest that outer hair cells are the initial site of degeneration caused by application of excess glutamate to the inner ear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:57:32