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Titolo:
Role of amino acids in cochlear degeneration: Deprivation of cystine induces death of cochlear hair cells of guinea pigs in vitro
Autore:
Sunami, K; Yamane, H; Konishi, K; Iguchi, H; Nakagawa, T; Shibata, S; Takayama, M; Nakai, Y;
Indirizzi:
Osakaapany Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, Osaka 5458585, J Osaka City Univ Osaka Japan 5458585 laryngol, Abeno Ku, Osaka 5458585, J Yodogawa Christian Hosp, Dept Otorhinolaryngol, Osaka, Japan Yodogawa Christian Hosp Osaka Japan Dept Otorhinolaryngol, Osaka, Japan Wakakusa Daiichi Hosp, Dept Otorhinolaryngol, Osaka, Japan Wakakusa Daiichi Hosp Osaka Japan , Dept Otorhinolaryngol, Osaka, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 1998, supplemento:, 538
pagine: 19 - 21
SICI:
0001-6489(1998):<19:ROAAIC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXICITY; LINE;
Keywords:
cell death; redox regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Sunami, K Osakai,ity Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, 1-4-3Asahi Mach Osaka City Univ 1-4-3 Asahi Machi Osaka Japan 5458585 sahi Mach
Citazione:
K. Sunami et al., "Role of amino acids in cochlear degeneration: Deprivation of cystine induces death of cochlear hair cells of guinea pigs in vitro", ACT OTO-LAR, 1998, pp. 19-21

Abstract

Redox regulation reportedly plays a role in maintaining cochlear homeostasis. However, little is known about the roles of oxidation-reduction systemsin the cochlea. We examined the role of the cystine/cysteine oxidation-reduction system in survival of cochlea hair cells in vitro. The survival of hair cells was evaluated in cochlea specimens following incubation with the medium supplemented with various concentrations of cystine. Dying hair cells were detected by the trypan blue extrusion method. The rates of cell death for both outer and inner hair cells increased significantly with a decrease in the concentration of cystine. In addition, the rate of cell death of IHCs tended to be higher than that of OHCs. These findings suggest that thecystine/cysteine system might be required for maintenance of homeostasis in cochlear hair cells, especially in IHCs.

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Documento generato il 28/11/20 alle ore 04:10:46